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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Vidal-Torres A, Fernández-Pastor B, García M, Ayet E, Cabot A, Burgueño J, Monroy X, Aubel B, Codony X, Romero L, Pascual R, Serafini MT, Encina G, Almansa C, Zamanillo D, Merlos M, Vela JM. Vidal-Torres A, et al. Among authors: merlos m. Acta Pharm Sin B. 2023 Jan;13(1):82-99. doi: 10.1016/j.apsb.2022.09.018. Epub 2022 Sep 25. Acta Pharm Sin B. 2023. PMID: 36815042 Free PMC article.
Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.
Planavila A, Rodríguez-Calvo R, Palomer X, Coll T, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M. Planavila A, et al. Among authors: merlos m. Biochim Biophys Acta. 2008 Jan-Feb;1781(1-2):26-35. doi: 10.1016/j.bbalip.2007.10.009. Epub 2007 Nov 12. Biochim Biophys Acta. 2008. PMID: 18036354
Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.
Romero L, Zamanillo D, Nadal X, Sánchez-Arroyos R, Rivera-Arconada I, Dordal A, Montero A, Muro A, Bura A, Segalés C, Laloya M, Hernández E, Portillo-Salido E, Escriche M, Codony X, Encina G, Burgueño J, Merlos M, Baeyens JM, Giraldo J, López-García JA, Maldonado R, Plata-Salamán CR, Vela JM. Romero L, et al. Among authors: merlos m. Br J Pharmacol. 2012 Aug;166(8):2289-306. doi: 10.1111/j.1476-5381.2012.01942.x. Br J Pharmacol. 2012. PMID: 22404321 Free PMC article.
Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).
Díaz JL, Cuberes R, Berrocal J, Contijoch M, Christmann U, Fernández A, Port A, Holenz J, Buschmann H, Laggner C, Serafini MT, Burgueño J, Zamanillo D, Merlos M, Vela JM, Almansa C. Díaz JL, et al. Among authors: merlos m. J Med Chem. 2012 Oct 11;55(19):8211-24. doi: 10.1021/jm3007323. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22784008
Sigma 1 receptor: a new therapeutic target for pain.
Zamanillo D, Romero L, Merlos M, Vela JM. Zamanillo D, et al. Among authors: merlos m. Eur J Pharmacol. 2013 Sep 15;716(1-3):78-93. doi: 10.1016/j.ejphar.2013.01.068. Epub 2013 Mar 13. Eur J Pharmacol. 2013. PMID: 23500210 Review.
156 results