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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Vidal-Torres A, Fernández-Pastor B, García M, Ayet E, Cabot A, Burgueño J, Monroy X, Aubel B, Codony X, Romero L, Pascual R, Serafini MT, Encina G, Almansa C, Zamanillo D, Merlos M, Vela JM. Vidal-Torres A, et al. Among authors: monroy x. Acta Pharm Sin B. 2023 Jan;13(1):82-99. doi: 10.1016/j.apsb.2022.09.018. Epub 2022 Sep 25. Acta Pharm Sin B. 2023. PMID: 36815042 Free PMC article.
Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.
Langa F, Codony X, Tovar V, Lavado A, Giménez E, Cozar P, Cantero M, Dordal A, Hernández E, Pérez R, Monroy X, Zamanillo D, Guitart X, Montoliu L. Langa F, et al. Among authors: monroy x. Eur J Neurosci. 2003 Oct;18(8):2188-96. doi: 10.1046/j.1460-9568.2003.02950.x. Eur J Neurosci. 2003. PMID: 14622179
Sigma receptors: biology and therapeutic potential.
Guitart X, Codony X, Monroy X. Guitart X, et al. Among authors: monroy x. Psychopharmacology (Berl). 2004 Jul;174(3):301-19. doi: 10.1007/s00213-004-1920-9. Epub 2004 Jun 10. Psychopharmacology (Berl). 2004. PMID: 15197533 Review.
4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain.
García M, Virgili M, Alonso M, Alegret C, Fernández B, Port A, Pascual R, Monroy X, Vidal-Torres A, Serafini MT, Vela JM, Almansa C. García M, et al. Among authors: monroy x. J Med Chem. 2020 Mar 12;63(5):2434-2454. doi: 10.1021/acs.jmedchem.9b01256. Epub 2019 Dec 5. J Med Chem. 2020. PMID: 31743642 Free article.
17 results