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Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
Takeuchi T, Maeta K, Ding X, Oe Y, Takeda A, Inoue M, Nagano S, Fujihara T, Matsuda S, Ishigaki S, Sahashi K, Minakawa EN, Mochizuki H, Neya M, Sobue G, Nagai Y. Takeuchi T, et al. Among authors: ishigaki s. Mol Ther Nucleic Acids. 2023 Jan 16;31:353-366. doi: 10.1016/j.omtn.2023.01.006. eCollection 2023 Mar 14. Mol Ther Nucleic Acids. 2023. PMID: 36817728 Free PMC article.
Importance of Functional Loss of FUS in FTLD/ALS.
Ishigaki S, Sobue G. Ishigaki S, et al. Front Mol Biosci. 2018 May 3;5:44. doi: 10.3389/fmolb.2018.00044. eCollection 2018. Front Mol Biosci. 2018. PMID: 29774215 Free PMC article. Review.
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka K, Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Tanaka F, Sobue G. Iguchi Y, et al. Among authors: ishigaki s. Brain. 2013 May;136(Pt 5):1371-82. doi: 10.1093/brain/awt029. Epub 2013 Feb 28. Brain. 2013. PMID: 23449777
328 results