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309 results

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Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure.
Beltra JC, Abdel-Hakeem MS, Manne S, Zhang Z, Huang H, Kurachi M, Su L, Picton L, Ngiow SF, Muroyama Y, Casella V, Huang YJ, Giles JR, Mathew D, Belman J, Klapholz M, Decaluwe H, Huang AC, Berger SL, Garcia KC, Wherry EJ. Beltra JC, et al. Among authors: garcia kc. Immunity. 2023 Dec 12;56(12):2699-2718.e11. doi: 10.1016/j.immuni.2023.11.005. Immunity. 2023. PMID: 38091951 Free PMC article.
Preclinical proof of principle for orally delivered Th17 antagonist miniproteins.
Berger S, Seeger F, Yu TY, Aydin M, Yang H, Rosenblum D, Guenin-Macé L, Glassman C, Arguinchona L, Sniezek C, Blackstone A, Carter L, Ravichandran R, Ahlrichs M, Murphy M, Pultz IS, Kang A, Bera AK, Stewart L, Garcia KC, Naik S, Spangler JB, Beigel F, Siebeck M, Gropp R, Baker D. Berger S, et al. Among authors: garcia kc. Cell. 2024 Aug 8;187(16):4305-4317.e18. doi: 10.1016/j.cell.2024.05.052. Epub 2024 Jun 26. Cell. 2024. PMID: 38936360 Free article.
Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo.
Ramos TL, Bolivar-Wagers S, Jin S, Thangavelu G, Simonetta F, Lin PY, Hirai T, Saha A, Koehn B, Su LL, Picton LK, Baker J, Lohmeyer JK, Riddle M, Eide C, Tolar J, Panoskaltsis-Mortari A, Wagner JE, Garcia KC, Negrin RS, Blazar BR. Ramos TL, et al. Among authors: garcia kc. Blood. 2023 Mar 16;141(11):1337-1352. doi: 10.1182/blood.2022018440. Blood. 2023. PMID: 36564052 Free PMC article.
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors.
Banhos Danneskiold-Samsøe N, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ. Banhos Danneskiold-Samsøe N, et al. Among authors: garcia kc. Cell Syst. 2024 Nov 20;15(11):1046-1060.e3. doi: 10.1016/j.cels.2024.10.004. Epub 2024 Nov 13. Cell Syst. 2024. PMID: 39541981
TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling.
Funa NS, Mjoseng HK, de Lichtenberg KH, Raineri S, Esen D, Egeskov-Madsen AR, Quaranta R, Jørgensen MC, Hansen MS, van Cuyl Kuylenstierna J, Jensen KB, Miao Y, Garcia KC, Seymour PA, Serup P. Funa NS, et al. Among authors: garcia kc. Stem Cell Reports. 2024 Jul 9;19(7):973-992. doi: 10.1016/j.stemcr.2024.05.010. Epub 2024 Jun 27. Stem Cell Reports. 2024. PMID: 38942030 Free PMC article.
Mucosal signatures of pathogenic T cells in HLA-B*27+ anterior uveitis and axial spondyloarthritis.
Paley MA, Yang X, Hassman LM, Penkava F, Garner LI, Paley GL, Linskey N, Agnew R, Arantes de Faria PH, Feng A, Li SY, Simone D, Roberson ED, Ruzycki PA, Esaulova E, Laurent J, Feigl-Lenzen L, Springer LE, Liu C, Gillespie GM, Bowness P, Garcia KC, Yokoyama WM. Paley MA, et al. Among authors: garcia kc. JCI Insight. 2024 Jul 18;9(16):e174776. doi: 10.1172/jci.insight.174776. JCI Insight. 2024. PMID: 39024572 Free PMC article.
Small but mighty: microexons in glucose homeostasis.
Garcia K, Gloyn AL. Garcia K, et al. Trends Genet. 2023 Jul;39(7):526-527. doi: 10.1016/j.tig.2023.04.003. Epub 2023 Apr 18. Trends Genet. 2023. PMID: 37080883 Free PMC article.
309 results