Gubler H - Search Results

1

Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the α-Helix Pocket on TEAD.

Mesrouze Y, Gubler H, Villard F, Boesch R, Ottl J, Kallen J, Reid PC, Scheufler C, Marzinzik AL, Chène P. Mesrouze Y, et al. Among authors: gubler h. ACS Chem Biol. 2023 Mar 17;18(3):643-651. doi: 10.1021/acschembio.2c00936. Epub 2023 Feb 24. ACS Chem Biol. 2023. PMID: 36825662

2

Assay data quality assessment.

Gubler H. Gubler H. Methods Mol Biol. 2009;552:79-95. doi: 10.1007/978-1-60327-317-6_6. Methods Mol Biol. 2009. PMID: 19513643 Review.

3

Gene-signature-derived IC₅₀s/EC₅₀s reflect the potency of causative upstream targets and downstream phenotypes.

Renner S, Bergsdorf C, Bouhelal R, Koziczak-Holbro M, Amati AM, Techer-Etienne V, Flotte L, Reymann N, Kapur K, Hoersch S, Oakeley EJ, Schuffenhauer A, Gubler H, Lounkine E, Farmer P. Renner S, et al. Among authors: gubler h. Sci Rep. 2020 Jun 15;10(1):9670. doi: 10.1038/s41598-020-66533-5. Sci Rep. 2020. PMID: 32541899 Free PMC article.

4

Compound set enrichment: a novel approach to analysis of primary HTS data.

Varin T, Gubler H, Parker CN, Zhang JH, Raman P, Ertl P, Schuffenhauer A. Varin T, et al. Among authors: gubler h. J Chem Inf Model. 2010 Dec 27;50(12):2067-78. doi: 10.1021/ci100203e. Epub 2010 Nov 12. J Chem Inf Model. 2010. PMID: 21073183

5

Comparison of variability and sensitivity between nuclear translocation and luciferase reporter gene assays.

Unterreiner V, Ibig-Rehm Y, Simonen M, Gubler H, Gabriel D. Unterreiner V, et al. Among authors: gubler h. J Biomol Screen. 2009 Jan;14(1):59-65. doi: 10.1177/1087057108328016. J Biomol Screen. 2009. PMID: 19171921

6

Helios: History and Anatomy of a Successful In-House Enterprise High-Throughput Screening and Profiling Data Analysis System.

Gubler H, Clare N, Galafassi L, Geissler U, Girod M, Herr G. Gubler H, et al. SLAS Discov. 2018 Jun;23(5):474-488. doi: 10.1177/2472555217752140. Epub 2018 Jan 25. SLAS Discov. 2018. PMID: 29370716 Free article.

7

Recommendations for the reduction of compound artifacts in time-resolved fluorescence resonance energy transfer assays.

Imbert PE, Unterreiner V, Siebert D, Gubler H, Parker C, Gabriel D. Imbert PE, et al. Among authors: gubler h. Assay Drug Dev Technol. 2007 Jun;5(3):363-72. doi: 10.1089/adt.2007.073. Assay Drug Dev Technol. 2007. PMID: 17638536

8

A multiparameter screening assay to assess the cytokine-induced expression of endothelial cell adhesion molecules.

Zerwes HG, Peter JC, Link M, Gubler H, Scheel G. Zerwes HG, et al. Among authors: gubler h. Anal Biochem. 2002 May 15;304(2):166-73. doi: 10.1006/abio.2002.5626. Anal Biochem. 2002. PMID: 12009692

9

Theoretical and experimental relationships between percent inhibition and IC50 data observed in high-throughput screening.

Gubler H, Schopfer U, Jacoby E. Gubler H, et al. J Biomol Screen. 2013 Jan;18(1):1-13. doi: 10.1177/1087057112455219. Epub 2012 Aug 1. J Biomol Screen. 2013. PMID: 22853931

10

Integration of multiple readouts into the z' factor for assay quality assessment.

Kümmel A, Gubler H, Gehin P, Beibel M, Gabriel D, Parker CN. Kümmel A, et al. Among authors: gubler h. J Biomol Screen. 2010 Jan;15(1):95-101. doi: 10.1177/1087057109351311. Epub 2009 Nov 25. J Biomol Screen. 2010. PMID: 19940084

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