Ouyang S - Search Results

1

Targeting STAT3-VISTA axis to suppress tumor aggression and burden in acute myeloid leukemia.

Mo J, Deng L, Peng K, Ouyang S, Ding W, Lou L, Lin Z, Zhu J, Li J, Zhang Q, Wang P, Wen Y, Chen X, Yue P, Lu JJ, Zhu K, Zheng Y, Wang Y, Zhang X. Mo J, et al. Among authors: ouyang s. J Hematol Oncol. 2023 Feb 27;16(1):15. doi: 10.1186/s13045-023-01410-y. J Hematol Oncol. 2023. PMID: 36849939 Free PMC article.

2

A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.

Zheng Q, Dong H, Mo J, Zhang Y, Huang J, Ouyang S, Shi S, Zhu K, Qu X, Hu W, Liu P, Wang Y, Zhang X. Zheng Q, et al. Among authors: ouyang s. Theranostics. 2021 Jan 1;11(2):824-840. doi: 10.7150/thno.49600. eCollection 2021. Theranostics. 2021. PMID: 33391507 Free PMC article.

3

Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).

Huang Q, Zhong Y, Li B, Ouyang S, Deng L, Mo J, Shi S, Lv N, Wu R, Liu P, Hu W, Zhang X, Wang Y. Huang Q, et al. Among authors: ouyang s. Eur J Med Chem. 2021 Oct 5;221:113525. doi: 10.1016/j.ejmech.2021.113525. Epub 2021 May 7. Eur J Med Chem. 2021. PMID: 34000483

4

The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts.

Zhong Y, Deng L, Shi S, Huang QY, Ou-Yang SM, Mo JS, Zhu K, Qu XM, Liu PQ, Wang YX, Zhang XL. Zhong Y, et al. Acta Pharmacol Sin. 2022 Apr;43(4):1013-1023. doi: 10.1038/s41401-021-00718-0. Epub 2021 Jul 15. Acta Pharmacol Sin. 2022. PMID: 34267347 Free PMC article.

5

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.

Ouyang S, Li H, Lou L, Huang Q, Zhang Z, Mo J, Li M, Lu J, Zhu K, Chu Y, Ding W, Zhu J, Lin Z, Zhong L, Wang J, Yue P, Turkson J, Liu P, Wang Y, Zhang X. Ouyang S, et al. Redox Biol. 2022 Jun;52:102317. doi: 10.1016/j.redox.2022.102317. Epub 2022 Apr 21. Redox Biol. 2022. PMID: 35483272 Free PMC article.

6

The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications.

Ouyang S, Zhang Q, Lou L, Zhu K, Li Z, Liu P, Zhang X. Ouyang S, et al. Front Pharmacol. 2022 Apr 27;13:871560. doi: 10.3389/fphar.2022.871560. eCollection 2022. Front Pharmacol. 2022. PMID: 35571098 Free PMC article. Review.

7

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma.

Ge Y, Deng JJ, Zhu J, Liu L, Ouyang S, Song Z, Zhang X, Xiong XF. Ge Y, et al. Among authors: ouyang s. Acta Pharm Sin B. 2022 Aug;12(8):3326-3340. doi: 10.1016/j.apsb.2022.04.016. Epub 2022 May 4. Acta Pharm Sin B. 2022. PMID: 35967274 Free PMC article.

8

Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.

Deng L, Mo J, Zhang Y, Peng K, Li H, Ouyang S, Feng Z, Fang W, Wei J, Rong D, Zhang X, Wang Y. Deng L, et al. Among authors: ouyang s. J Med Chem. 2022 Oct 13;65(19):13094-13111. doi: 10.1021/acs.jmedchem.2c00940. Epub 2022 Sep 28. J Med Chem. 2022. PMID: 36170649

9

Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.

Li H, Ouyang S, Zhang Y, Peng K, Fang W, Liu Z, Wang CY, Zhang X, Wang Y. Li H, et al. Among authors: ouyang s. Eur J Med Chem. 2022 Dec 15;244:114858. doi: 10.1016/j.ejmech.2022.114858. Epub 2022 Oct 19. Eur J Med Chem. 2022. PMID: 36283181

10

Metabolic Reprogramming Driven by IGF2BP3 Promotes Acquired Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer.

Lin Z, Li J, Zhang J, Feng W, Lu J, Ma X, Ding W, Ouyang S, Lu J, Yue P, Wan G, Liu P, Zhang X. Lin Z, et al. Among authors: ouyang s. Cancer Res. 2023 Jul 5;83(13):2187-2207. doi: 10.1158/0008-5472.CAN-22-3059. Cancer Res. 2023. PMID: 37061993

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