Wang Y - Search Results

1

Targeting STAT3-VISTA axis to suppress tumor aggression and burden in acute myeloid leukemia.

Mo J, Deng L, Peng K, Ouyang S, Ding W, Lou L, Lin Z, Zhu J, Li J, Zhang Q, Wang P, Wen Y, Chen X, Yue P, Lu JJ, Zhu K, Zheng Y, Wang Y, Zhang X. Mo J, et al. Among authors: wang y, wang p. J Hematol Oncol. 2023 Feb 27;16(1):15. doi: 10.1186/s13045-023-01410-y. J Hematol Oncol. 2023. PMID: 36849939 Free PMC article.

2

Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?

Huang Q, Zhong Y, Dong H, Zheng Q, Shi S, Zhu K, Qu X, Hu W, Zhang X, Wang Y. Huang Q, et al. Among authors: wang y. Eur J Med Chem. 2020 Feb 1;187:111922. doi: 10.1016/j.ejmech.2019.111922. Epub 2019 Nov 28. Eur J Med Chem. 2020. PMID: 31810784 Review.

3

A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.

Zheng Q, Dong H, Mo J, Zhang Y, Huang J, Ouyang S, Shi S, Zhu K, Qu X, Hu W, Liu P, Wang Y, Zhang X. Zheng Q, et al. Among authors: wang y. Theranostics. 2021 Jan 1;11(2):824-840. doi: 10.7150/thno.49600. eCollection 2021. Theranostics. 2021. PMID: 33391507 Free PMC article.

4

Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).

Huang Q, Zhong Y, Li B, Ouyang S, Deng L, Mo J, Shi S, Lv N, Wu R, Liu P, Hu W, Zhang X, Wang Y. Huang Q, et al. Among authors: wang y. Eur J Med Chem. 2021 Oct 5;221:113525. doi: 10.1016/j.ejmech.2021.113525. Epub 2021 May 7. Eur J Med Chem. 2021. PMID: 34000483

5

The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts.

Zhong Y, Deng L, Shi S, Huang QY, Ou-Yang SM, Mo JS, Zhu K, Qu XM, Liu PQ, Wang YX, Zhang XL. Zhong Y, et al. Among authors: wang yx. Acta Pharmacol Sin. 2022 Apr;43(4):1013-1023. doi: 10.1038/s41401-021-00718-0. Epub 2021 Jul 15. Acta Pharmacol Sin. 2022. PMID: 34267347 Free PMC article.

6

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.

Ouyang S, Li H, Lou L, Huang Q, Zhang Z, Mo J, Li M, Lu J, Zhu K, Chu Y, Ding W, Zhu J, Lin Z, Zhong L, Wang J, Yue P, Turkson J, Liu P, Wang Y, Zhang X. Ouyang S, et al. Among authors: wang j, wang y. Redox Biol. 2022 Jun;52:102317. doi: 10.1016/j.redox.2022.102317. Epub 2022 Apr 21. Redox Biol. 2022. PMID: 35483272 Free PMC article.

7

Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.

Deng L, Mo J, Zhang Y, Peng K, Li H, Ouyang S, Feng Z, Fang W, Wei J, Rong D, Zhang X, Wang Y. Deng L, et al. Among authors: wang y. J Med Chem. 2022 Oct 13;65(19):13094-13111. doi: 10.1021/acs.jmedchem.2c00940. Epub 2022 Sep 28. J Med Chem. 2022. PMID: 36170649

8

Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.

Li H, Ouyang S, Zhang Y, Peng K, Fang W, Liu Z, Wang CY, Zhang X, Wang Y. Li H, et al. Among authors: wang y, wang cy. Eur J Med Chem. 2022 Dec 15;244:114858. doi: 10.1016/j.ejmech.2022.114858. Epub 2022 Oct 19. Eur J Med Chem. 2022. PMID: 36283181

9

Reprogramming of TAMs via the STAT3/CD47-SIRPα axis promotes acquired resistance to EGFR-TKIs in lung cancer.

Lu J, Li J, Lin Z, Li H, Lou L, Ding W, Ouyang S, Wu Y, Wen Y, Chen X, Yue P, Wang Y, Liu P, Lu J, Zhang J, Feng W, Zhang X. Lu J, et al. Among authors: wang y. Cancer Lett. 2023 Jun 28;564:216205. doi: 10.1016/j.canlet.2023.216205. Epub 2023 May 4. Cancer Lett. 2023. PMID: 37146936

10

Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.

Liu L, Song Z, Fan G, Lou L, Wang Y, Zhang X, Xiong XF. Liu L, et al. Among authors: wang y. Bioorg Med Chem. 2023 Oct 1;93:117457. doi: 10.1016/j.bmc.2023.117457. Epub 2023 Aug 25. Bioorg Med Chem. 2023. PMID: 37688996

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