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Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice.
Kenney AD, Zani A, Kawahara J, Eddy AC, Wang XL, Mahesh KC, Lu M, Thomas J, Kohlmeier JE, Suthar MS, Hemann EA, Li J, Peeples ME, Hall-Stoodley L, Forero A, Cai C, Ma J, Yount JS. Kenney AD, et al. Among authors: mahesh kc. EMBO Rep. 2023 Apr 5;24(4):e56660. doi: 10.15252/embr.202256660. Epub 2023 Mar 7. EMBO Rep. 2023. PMID: 36880581 Free PMC article.
A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike.
Zhang Y, Lu M, Mahesh KC, Kim E, Shamseldin MM, Ye C, Dravid P, Chamblee M, Park JG, Hall JM, Trivedi S, Chaiwatpongsakorn S, Kenny AD, Murthy SS, Sharma H, Liang X, Yount JS, Kapoor A, Martinez-Sobrido L, Dubey P, Boyaka PN, Peeples ME, Li J. Zhang Y, et al. Among authors: mahesh kc. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2201616119. doi: 10.1073/pnas.2201616119. Epub 2022 Jul 27. Proc Natl Acad Sci U S A. 2022. PMID: 35895717 Free PMC article.
SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern.
Lu M, Chamblee M, Zhang Y, Ye C, Dravid P, Park JG, Mahesh KC, Trivedi S, Murthy S, Sharma H, Cassady C, Chaiwatpongsakorn S, Liang X, Yount JS, Boyaka PN, Peeples ME, Martinez-Sobrido L, Kapoor A, Li J. Lu M, et al. Among authors: mahesh kc. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2110105119. doi: 10.1073/pnas.2110105119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994646 Free PMC article.
Prime-Pull Immunization of Mice with a BcfA-Adjuvanted Vaccine Elicits Sustained Mucosal Immunity That Prevents SARS-CoV-2 Infection and Pathology.
Shamseldin MM, Kenney A, Zani A, Evans JP, Zeng C, Read KA, Hall JM, Chaiwatpongsakorn S, Mahesh KC, Lu M, Eltobgy M, Denz P, Deora R, Li J, Peeples ME, Oestreich KJ, Liu SL, Corps KN, Yount JS, Dubey P. Shamseldin MM, et al. Among authors: mahesh kc. J Immunol. 2023 May 1;210(9):1257-1271. doi: 10.4049/jimmunol.2200297. J Immunol. 2023. PMID: 36881867 Free PMC article.
Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective.
Zhang Y, Chamblee M, Xu J, Qu P, Shamseldin MM, Yoo SJ, Misny J, Thongpan I, Kc M, Hall JM, Gupta YA, Evans JP, Lu M, Ye C, Hsu CC, Liang X, Martinez-Sobrido L, Yount JS, Boyaka PN, Liu SL, Dubey P, Peeples ME, Li J. Zhang Y, et al. Among authors: kc m. Nat Commun. 2024 Jul 3;15(1):5589. doi: 10.1038/s41467-024-49443-2. Nat Commun. 2024. PMID: 38961063 Free PMC article.
A next-generation intranasal trivalent MMS vaccine induces durable and broad protection against SARS-CoV-2 variants of concern.
Xu J, Zhang Y, Qu P, Shamseldin MM, Yoo SJ, Misny J, Thongpan I, Kc M, Hall JM, Evans JP, Eltobgy M, Lu M, Ye C, Chamblee M, Liang X, Martinez-Sobrido L, Amer AO, Yount JS, Boyaka PN, Peeples ME, Liu SL, Dubey P, Li J. Xu J, et al. Among authors: kc m. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2220403120. doi: 10.1073/pnas.2220403120. Epub 2023 Oct 5. Proc Natl Acad Sci U S A. 2023. PMID: 37796985 Free PMC article.
24 results