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Page 1
Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape.
Boddu PC, Gupta A, Roy R, De La Pena Avalos B, Herrero AO, Neuenkirchen N, Zimmer J, Chandhok N, King D, Nannya Y, Ogawa S, Lin H, Simon M, Dray E, Kupfer G, Verma AK, Neugebauer KM, Pillai MM. Boddu PC, et al. Among authors: zimmer j. bioRxiv [Preprint]. 2023 Feb 26:2023.02.25.530019. doi: 10.1101/2023.02.25.530019. bioRxiv. 2023. Update in: Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032. PMID: 36891287 Free PMC article. Updated. Preprint.
Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies.
Biancon G, Joshi P, Zimmer JT, Hunck T, Gao Y, Lessard MD, Courchaine E, Barentine AES, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon MD, Neugebauer KM, Tebaldi T, Halene S. Biancon G, et al. Among authors: zimmer jt. Mol Cell. 2022 Mar 17;82(6):1107-1122.e7. doi: 10.1016/j.molcel.2022.02.025. Mol Cell. 2022. PMID: 35303483 Free PMC article.
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape.
Boddu PC, Gupta AK, Roy R, De La Peña Avalos B, Olazabal-Herrero A, Neuenkirchen N, Zimmer JT, Chandhok NS, King D, Nannya Y, Ogawa S, Lin H, Simon MD, Dray E, Kupfer GM, Verma A, Neugebauer KM, Pillai MM. Boddu PC, et al. Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032. Epub 2024 Mar 22. Mol Cell. 2024. PMID: 38521065
Functional elements of the cis-regulatory lincRNA-p21.
Winkler L, Jimenez M, Zimmer JT, Williams A, Simon MD, Dimitrova N. Winkler L, et al. Cell Rep. 2022 Apr 19;39(3):110687. doi: 10.1016/j.celrep.2022.110687. Cell Rep. 2022. PMID: 35443176 Free PMC article.
p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis.
Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. Olivero CE, et al. Among authors: zimmer j. Mol Cell. 2020 Feb 20;77(4):761-774.e8. doi: 10.1016/j.molcel.2019.12.014. Epub 2020 Jan 20. Mol Cell. 2020. PMID: 31973890 Free PMC article.
Acetyl-methyllysine marks chromatin at active transcription start sites.
Lu-Culligan WJ, Connor LJ, Xie Y, Ekundayo BE, Rose BT, Machyna M, Pintado-Urbanc AP, Zimmer JT, Vock IW, Bhanu NV, King MC, Garcia BA, Bleichert F, Simon MD. Lu-Culligan WJ, et al. Among authors: zimmer jt. Nature. 2023 Oct;622(7981):173-179. doi: 10.1038/s41586-023-06565-9. Epub 2023 Sep 20. Nature. 2023. PMID: 37731000 Free PMC article.
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC.
Swartzel JC, Bond MJ, Pintado-Urbanc AP, Daftary M, Krone MW, Douglas T, Carder EJ, Zimmer JT, Maeda T, Simon MD, Crews CM. Swartzel JC, et al. Among authors: zimmer jt. ACS Chem Biol. 2022 Jul 15;17(7):1789-1798. doi: 10.1021/acschembio.2c00145. Epub 2022 Jun 24. ACS Chem Biol. 2022. PMID: 35749470 Free PMC article.
808 results