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Identifying multiscale translational safety biomarkers using a network-based systems approach.
Callegaro G, Schimming JP, Piñero González J, Kunnen SJ, Wijaya L, Trairatphisan P, van den Berk L, Beetsma K, Furlong LI, Sutherland JJ, Mollon J, Stevens JL, van de Water B. Callegaro G, et al. Among authors: van de water b, van den berk l. iScience. 2023 Jan 31;26(3):106094. doi: 10.1016/j.isci.2023.106094. eCollection 2023 Mar 17. iScience. 2023. PMID: 36895646 Free PMC article.
Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.
van de Water B, Tijdens IB, Verbrugge A, Huigsloot M, Dihal AA, Stevens JL, Jaken S, Mulder GJ. van de Water B, et al. J Biol Chem. 2000 Aug 18;275(33):25805-13. doi: 10.1074/jbc.M001680200. J Biol Chem. 2000. PMID: 10823823 Free article.
Decreased phosphorylation of focal adhesion kinase and paxillin is associated with loss of focal adhesions and stress fibers and precedes the onset of apoptosis (van de Water, B., Nagelkerke, J. F., and Stevens, J. L. (1999) J. Biol. Chem. 274, 13328-1 …
Decreased phosphorylation of focal adhesion kinase and paxillin is associated with loss of focal adhesions and stress fibers and precedes th …
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.
Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, Rainbow L, Fang Y, Sutherland JJ, Ellis EC, Ingelman-Sundberg M, Fenwick SW, Goldring CE, van de Water B, Stevens JL, Park BK. Copple IM, et al. Among authors: van de water b. Arch Toxicol. 2019 Feb;93(2):385-399. doi: 10.1007/s00204-018-2354-1. Epub 2018 Nov 13. Arch Toxicol. 2019. PMID: 30426165 Free PMC article.
High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.
Hiemstra S, Ramaiahgari SC, Wink S, Callegaro G, Coonen M, Meerman J, Jennen D, van den Nieuwendijk K, Dankers A, Snoeys J, de Bont H, Price L, van de Water B. Hiemstra S, et al. Among authors: van den nieuwendijk k, van de water b, de bont h. Arch Toxicol. 2019 Oct;93(10):2895-2911. doi: 10.1007/s00204-019-02552-0. Epub 2019 Aug 27. Arch Toxicol. 2019. PMID: 31552476
262 results