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Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.
Alarcón-Arís D, Pavia-Collado R, Miquel-Rio L, Coppola-Segovia V, Ferrés-Coy A, Ruiz-Bronchal E, Galofré M, Paz V, Campa L, Revilla R, Montefeltro A, Kordower JH, Vila M, Artigas F, Bortolozzi A. Alarcón-Arís D, et al. Among authors: campa l. EBioMedicine. 2020 Sep;59:102944. doi: 10.1016/j.ebiom.2020.102944. Epub 2020 Aug 15. EBioMedicine. 2020. PMID: 32810825 Free PMC article.
M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's disease.
Fernández-García S, Conde-Berriozabal S, García-García E, Gort-Paniello C, Bernal-Casas D, García-Díaz Barriga G, López-Gil J, Muñoz-Moreno E, Soria G, Campa L, Artigas F, Rodríguez MJ, Alberch J, Masana M. Fernández-García S, et al. Among authors: campa l. Elife. 2020 Oct 5;9:e57017. doi: 10.7554/eLife.57017. Elife. 2020. PMID: 33016873 Free PMC article.
Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.
Pavia-Collado R, Cóppola-Segovia V, Miquel-Rio L, Alarcón-Aris D, Rodríguez-Aller R, Torres-López M, Paz V, Ruiz-Bronchal E, Campa L, Artigas F, Montefeltro A, Revilla R, Bortolozzi A. Pavia-Collado R, et al. Among authors: campa l. Int J Mol Sci. 2021 Mar 13;22(6):2939. doi: 10.3390/ijms22062939. Int J Mol Sci. 2021. PMID: 33805843 Free PMC article.
48 results