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Page 1
MYC determines lineage commitment in KRAS-driven primary liver cancer development.
D'Artista L, Moschopoulou AA, Barozzi I, Craig AJ, Seehawer M, Herrmann L, Minnich M, Kang TW, Rist E, Henning M, Klotz S, Heinzmann F, Harbig J, Sipos B, Longerich T, Eilers M, Dauch D, Zuber J, Wang XW, Zender L. D'Artista L, et al. Among authors: dauch d. J Hepatol. 2023 Jul;79(1):141-149. doi: 10.1016/j.jhep.2023.02.039. Epub 2023 Mar 9. J Hepatol. 2023. PMID: 36906109 Free PMC article.
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L. Kang TW, et al. Among authors: dauch d. Nature. 2011 Nov 9;479(7374):547-51. doi: 10.1038/nature10599. Nature. 2011. PMID: 22080947
A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.
Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L. Wuestefeld T, et al. Among authors: dauch d. Cell. 2013 Apr 11;153(2):389-401. doi: 10.1016/j.cell.2013.03.026. Cell. 2013. PMID: 23582328 Free article.
Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.
Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Bermejo JL, Gretz N, Zender L, Schirmacher P, Beck M, Singer S. Winkler J, et al. Among authors: dauch d. Hepatology. 2014 Sep;60(3):884-95. doi: 10.1002/hep.27207. Epub 2014 Jul 17. Hepatology. 2014. PMID: 24799195
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.
Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S, Zender L. Rudalska R, et al. Among authors: dauch d. Nat Med. 2014 Oct;20(10):1138-46. doi: 10.1038/nm.3679. Epub 2014 Sep 14. Nat Med. 2014. PMID: 25216638 Free PMC article.
Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
Holzer K, Drucker E, Roessler S, Dauch D, Heinzmann F, Waldburger N, Eiteneuer EM, Herpel E, Breuhahn K, Zender L, Schirmacher P, Ori A, Singer S. Holzer K, et al. Among authors: dauch d. Am J Pathol. 2017 Feb;187(2):228-235. doi: 10.1016/j.ajpath.2016.09.022. Epub 2016 Dec 7. Am J Pathol. 2017. PMID: 27939741 Free article.
Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.
Wentsch HK, Walter NM, Bührmann M, Mayer-Wrangowski S, Rauh D, Zaman GJR, Willemsen-Seegers N, Buijsman RC, Henning M, Dauch D, Zender L, Laufer S. Wentsch HK, et al. Among authors: dauch d. Angew Chem Int Ed Engl. 2017 May 2;56(19):5363-5367. doi: 10.1002/anie.201701185. Epub 2017 Apr 11. Angew Chem Int Ed Engl. 2017. PMID: 28397331
Cardiac glycosides are broad-spectrum senolytics.
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J. Guerrero A, et al. Among authors: dauch d. Nat Metab. 2019 Nov;1(11):1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21. Nat Metab. 2019. PMID: 31799499 Free PMC article.
Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S. Röhm S, et al. Among authors: dauch d. Eur J Med Chem. 2020 Dec 15;208:112721. doi: 10.1016/j.ejmech.2020.112721. Epub 2020 Aug 20. Eur J Med Chem. 2020. PMID: 33035818
26 results