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Page 1
Short-term molecular consequences of chromosome mis-segregation for genome stability.
Garribba L, De Feudis G, Martis V, Galli M, Dumont M, Eliezer Y, Wardenaar R, Ippolito MR, Iyer DR, Tijhuis AE, Spierings DCJ, Schubert M, Taglietti S, Soriani C, Gemble S, Basto R, Rhind N, Foijer F, Ben-David U, Fachinetti D, Doksani Y, Santaguida S. Garribba L, et al. Among authors: ippolito mr. Nat Commun. 2023 Mar 11;14(1):1353. doi: 10.1038/s41467-023-37095-7. Nat Commun. 2023. PMID: 36906648 Free PMC article.
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Bernhard SV, Kazachkova M, Tang H, Ippolito MR, Laue K, Zerbib J, Malaby HLH, Jones A, Stautmeister LM, Bockaj I, Wardenaar R, Lyons N, Nagaraja A, Bass AJ, Spierings DCJ, Foijer F, Beroukhim R, Santaguida S, Golub TR, Stumpff J, Storchová Z, Ben-David U. Cohen-Sharir Y, et al. Among authors: ippolito mr. Nature. 2021 Feb;590(7846):486-491. doi: 10.1038/s41586-020-03114-6. Epub 2021 Jan 27. Nature. 2021. PMID: 33505028 Free PMC article.
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.
Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S. Martin S, et al. Among authors: ippolito mr. Science. 2024 Aug 30;385(6712):eadj7446. doi: 10.1126/science.adj7446. Epub 2024 Aug 30. Science. 2024. PMID: 39208097 Free PMC article.
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage.
Zerbib J, Ippolito MR, Eliezer Y, De Feudis G, Reuveni E, Savir Kadmon A, Martin S, Viganò S, Leor G, Berstler J, Muenzner J, Mülleder M, Campagnolo EM, Shulman ED, Chang T, Rubolino C, Laue K, Cohen-Sharir Y, Scorzoni S, Taglietti S, Ratti A, Stossel C, Golan T, Nicassio F, Ruppin E, Ralser M, Vazquez F, Ben-David U, Santaguida S. Zerbib J, et al. Among authors: ippolito mr. Nat Commun. 2024 Sep 9;15(1):7772. doi: 10.1038/s41467-024-52176-x. Nat Commun. 2024. PMID: 39251587 Free PMC article.
Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells.
Ippolito MR, Zerbib J, Eliezer Y, Reuveni E, Viganò S, De Feudis G, Shulman ED, Savir Kadmon A, Slutsky R, Chang T, Campagnolo EM, Taglietti S, Scorzoni S, Gianotti S, Martin S, Muenzner J, Mülleder M, Rozenblum N, Rubolino C, Ben-Yishay T, Laue K, Cohen-Sharir Y, Vigorito I, Nicassio F, Ruppin E, Ralser M, Vazquez F, Santaguida S, Ben-David U. Ippolito MR, et al. Cancer Discov. 2024 Dec 2;14(12):2532-2553. doi: 10.1158/2159-8290.CD-23-0309. Cancer Discov. 2024. PMID: 39247952
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity.
Musiani D, Bok J, Massignani E, Wu L, Tabaglio T, Ippolito MR, Cuomo A, Ozbek U, Zorgati H, Ghoshdastider U, Robinson RC, Guccione E, Bonaldi T. Musiani D, et al. Among authors: ippolito mr. Sci Signal. 2019 Apr 2;12(575):eaat8388. doi: 10.1126/scisignal.aat8388. Sci Signal. 2019. PMID: 30940768
High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors.
Zheng S, Raz L, Zhou L, Cohen-Sharir Y, Tian R, Ippolito MR, Gianotti S, Saad R, Wardenaar R, Broekhuis M, Suarez Peredo Rodriguez M, Wobben S, van den Brink A, Bakker P, Santaguida S, Foijer F, Ben-David U. Zheng S, et al. Among authors: ippolito mr. EMBO Rep. 2025 Jan 21. doi: 10.1038/s44319-024-00363-8. Online ahead of print. EMBO Rep. 2025. PMID: 39838194 Free article.
13 results