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Parasite and host kinases as targets for antimalarials.
Ong HW, Adderley J, Tobin AB, Drewry DH, Doerig C. Ong HW, et al. Among authors: tobin ab. Expert Opin Ther Targets. 2023 Feb;27(2):151-169. doi: 10.1080/14728222.2023.2185511. Epub 2023 Mar 20. Expert Opin Ther Targets. 2023. PMID: 36942408 Free article. Review.
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Jörg M, van der Westhuizen ET, Lu Y, Christopher Choy KH, Shackleford DM, Khajehali E, Tobin AB, Thal DM, Capuano B, Christopoulos A, Valant C, Scammells PJ. Jörg M, et al. Among authors: tobin ab. Eur J Med Chem. 2023 Oct 5;258:115588. doi: 10.1016/j.ejmech.2023.115588. Epub 2023 Jul 1. Eur J Med Chem. 2023. PMID: 37423123 Free PMC article.
Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment.
Brettell SB, Janha O, Begen A, Cann G, Sharma S, Olaniyan N, Yelland T, Hole AJ, Alam B, Mayville E, Gillespie R, Capper M, Fidock DA, Milligan G, Clarke DJ, Tobin AB, Jamieson AG. Brettell SB, et al. Among authors: tobin ab. J Med Chem. 2024 Nov 14;67(21):18895-18910. doi: 10.1021/acs.jmedchem.4c01300. Epub 2024 Oct 23. J Med Chem. 2024. PMID: 39441986 Free PMC article.
The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani I, Petragnano F, Wang Z, Edwards R, Telugu N, Pietrantoni I, Zabel U, Zauber H, Grieben M, Terzenidou ME, Di Gregorio J, Pellegrini C, Santini S Jr, Taddei AR, Pohl B, Aringhieri S, Carli M, Aloisi G, Marampon F, Charlesworth E, Roman A, Diecke S, Flati V, Giorgi F, Amicarelli F, Tobin AB, Scarselli M, Tokatlidis K, Rossi M, Lohse MJ, Annibale P, Maggio R. Fasciani I, et al. Among authors: tobin ab. PLoS Biol. 2024 Apr 29;22(4):e3002582. doi: 10.1371/journal.pbio.3002582. eCollection 2024 Apr. PLoS Biol. 2024. PMID: 38683874 Free PMC article.
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. Among authors: tobin ab. Nat Commun. 2023 Sep 6;14(1):5440. doi: 10.1038/s41467-023-41199-5. Nat Commun. 2023. PMID: 37673901 Free PMC article.
152 results