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An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.
Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL. Munkacsi AB, et al. J Biol Chem. 2011 Jul 8;286(27):23842-51. doi: 10.1074/jbc.M111.227645. Epub 2011 Apr 13. J Biol Chem. 2011. PMID: 21489983 Free PMC article.
A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.
Ruggles KV, Garbarino J, Liu Y, Moon J, Schneider K, Henneberry A, Billheimer J, Millar JS, Marchadier D, Valasek MA, Joblin-Mills A, Gulati S, Munkacsi AB, Repa JJ, Rader D, Sturley SL. Ruggles KV, et al. Among authors: munkacsi ab. J Biol Chem. 2014 Feb 14;289(7):4417-31. doi: 10.1074/jbc.M113.515197. Epub 2013 Nov 22. J Biol Chem. 2014. PMID: 24273168 Free PMC article.
Sterols and sphingolipids: dynamic duo or partners in crime?
Gulati S, Liu Y, Munkacsi AB, Wilcox L, Sturley SL. Gulati S, et al. Among authors: munkacsi ab. Prog Lipid Res. 2010 Oct;49(4):353-65. doi: 10.1016/j.plipres.2010.03.003. Epub 2010 Apr 1. Prog Lipid Res. 2010. PMID: 20362613 Free PMC article. Review.
Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response.
Shechtman CF, Henneberry AL, Seimon TA, Tinkelenberg AH, Wilcox LJ, Lee E, Fazlollahi M, Munkacsi AB, Bussemaker HJ, Tabas I, Sturley SL. Shechtman CF, et al. Among authors: munkacsi ab. J Biol Chem. 2011 Apr 8;286(14):11951-9. doi: 10.1074/jbc.M110.215038. Epub 2011 Jan 25. J Biol Chem. 2011. PMID: 21266578 Free PMC article.
30 results