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L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase.
Blachier J, Cleret A, Guerin N, Gil C, Fanjat JM, Tavernier F, Vidault L, Gallix F, Rama N, Rossignol R, Piedrahita D, Andrivon A, Châlons-Cottavoz M, Aguera K, Gay F, Horand F, Laperrousaz B. Blachier J, et al. Among authors: gallix f. Exp Cell Res. 2023 May 15;426(2):113568. doi: 10.1016/j.yexcr.2023.113568. Epub 2023 Mar 24. Exp Cell Res. 2023. PMID: 36967104