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Molecular Analysis of the Superior Efficacy of a Dual Epidermal Growth Factor Receptor (EGFR)-DNA-Targeting Combi-Molecule in Comparison with Its Putative Prodrugs 6-Mono-Alkylamino- and 6,6-Dialkylaminoquinazoline in a Human Osteosarcoma Xenograft Model.
Facchin C, Fraga-Timiraos AB, Schmitt J, Babaa N, Pannu N, Aliaga A, Larroque AL, Jean-Claude BJ. Facchin C, et al. Among authors: schmitt j. Cells. 2023 Mar 16;12(6):914. doi: 10.3390/cells12060914. Cells. 2023. PMID: 36980255 Free PMC article.
Design and Synthesis of a Trifunctional Molecular System "Programmed" to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells.
Schmitt J, Huang S, Goodfellow E, Williams C, Jean-Claude BJ. Schmitt J, et al. J Med Chem. 2020 Jun 11;63(11):5752-5762. doi: 10.1021/acs.jmedchem.9b02008. Epub 2020 Jun 2. J Med Chem. 2020. PMID: 32484346
Mechanisms and Antitumor Activity of a Binary EGFR/DNA-Targeting Strategy Overcomes Resistance of Glioblastoma Stem Cells to Temozolomide.
Sharifi Z, Abdulkarim B, Meehan B, Rak J, Daniel P, Schmitt J, Lauzon N, Eppert K, Duncan HM, Petrecca K, Guiot MC, Jean-Claude B, Sabri S. Sharifi Z, et al. Among authors: schmitt j. Clin Cancer Res. 2019 Dec 15;25(24):7594-7608. doi: 10.1158/1078-0432.CCR-19-0955. Epub 2019 Sep 20. Clin Cancer Res. 2019. PMID: 31540977
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy.
Raj Murthi S, Petry A, Shashikadze B, Stöckl JB, Schmid M, Santamaria G, Klingel K, Kračun D, Chen X, Bauer S, Schmitt JP, Flenkenthaler F, Gorham J, Toepfer CN, Potěšil D, Hruška P, Zdráhal Z, Mayer Z, Klop M, Lehmann L, Qin Y, Papanakli L, Spielmann N, Moretti A, Fröhlich T, Ewert P, Holdenrieder S, Seidman JG, Seidman CE, Görlach A, Wolf CM. Raj Murthi S, et al. Among authors: schmitt jp. Sci Rep. 2025 Jan 16;15(1):2132. doi: 10.1038/s41598-025-85187-9. Sci Rep. 2025. PMID: 39820339 Free PMC article.
2,278 results