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A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model.
Pallarès V, Unzueta U, Falgàs A, Aviñó A, Núñez Y, García-León A, Sánchez-García L, Serna N, Gallardo A, Alba-Castellón L, Álamo P, Sierra J, Cedó L, Eritja R, Villaverde A, Vázquez E, Casanova I, Mangues R. Pallarès V, et al. Biomaterials. 2022 Jan;280:121258. doi: 10.1016/j.biomaterials.2021.121258. Epub 2021 Nov 24. Biomaterials. 2022. PMID: 34847435 Free article.
A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice.
Falgàs A, Garcia-León A, Núñez Y, Serna N, Sánchez-Garcia L, Unzueta U, Voltà-Durán E, Aragó M, Álamo P, Alba-Castellón L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. Falgàs A, et al. Biomed Pharmacother. 2022 Jun;150:112940. doi: 10.1016/j.biopha.2022.112940. Epub 2022 Apr 11. Biomed Pharmacother. 2022. PMID: 35421785 Free article.
Paradoxical cell targeting of calreticulin-empowered, protein-only nanoparticles.
Parladé E, García-Leon A, Voltà-Durán E, Unzueta U, Mangues R, Casanova I, Villaverde A, Vázquez E. Parladé E, et al. Among authors: garcia leon a. Eur J Pharm Biopharm. 2024 Sep;202:114410. doi: 10.1016/j.ejpb.2024.114410. Epub 2024 Jul 14. Eur J Pharm Biopharm. 2024. PMID: 39004320 Free article.
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight From Mouse Models.
Cedó L, Metso J, Santos D, García-León A, Plana N, Sabate-Soler S, Rotllan N, Rivas-Urbina A, Méndez-Lara KA, Tondo M, Girona J, Julve J, Pallarès V, Benitez-Amaro A, Llorente-Cortes V, Pérez A, Gómez-Coronado D, Ruotsalainen AK, Levonen AL, Sanchez-Quesada JL, Masana L, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Blanco-Vaca F, Escolà-Gil JC. Cedó L, et al. Circ Res. 2020 Aug 28;127(6):778-792. doi: 10.1161/CIRCRESAHA.119.316424. Epub 2020 Jun 4. Circ Res. 2020. PMID: 32495699
Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness.
Revilla G, Pons MP, Baila-Rueda L, García-León A, Santos D, Cenarro A, Magalhaes M, Blanco RM, Moral A, Ignacio Pérez J, Sabé G, González C, Fuste V, Lerma E, Faria MDS, de Leiva A, Corcoy R, Carles Escolà-Gil J, Mato E. Revilla G, et al. Sci Rep. 2019 Jul 16;9(1):10260. doi: 10.1038/s41598-019-46727-2. Sci Rep. 2019. PMID: 31311983 Free PMC article.
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