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Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade.
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Mahmood M, et al. Among authors: park t. bioRxiv [Preprint]. 2023 Mar 23:2023.03.21.533091. doi: 10.1101/2023.03.21.533091. bioRxiv. 2023. Update in: Nat Cancer. 2024 Apr;5(4):659-672. doi: 10.1038/s43018-023-00721-w PMID: 36993533 Free PMC article. Updated. Preprint.
Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta-Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Boscenco S, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Mitchell L, Blyth K, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Mahmood M, et al. Among authors: park t. Nat Cancer. 2024 Apr;5(4):659-672. doi: 10.1038/s43018-023-00721-w. Epub 2024 Jan 29. Nat Cancer. 2024. PMID: 38286828 Free PMC article.
Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes.
Kim M, Gorelick AN, Vàzquez-García I, Williams MJ, Salehi S, Shi H, Weiner AC, Ceglia N, Funnell T, Park T, Boscenco S, O'Flanagan CH, Jiang H, Grewal D, Tang C, Rusk N, Gammage PA, McPherson A, Aparicio S, Shah SP, Reznik E. Kim M, et al. Among authors: park t. Nat Genet. 2024 May;56(5):889-899. doi: 10.1038/s41588-024-01724-8. Epub 2024 May 13. Nat Genet. 2024. PMID: 38741018 Free PMC article.
Obesity-dependent selection of driver mutations in cancer.
Tang C, Castillon VJ, Waters M, Fong C, Park T, Boscenco S, Kim S, Pekala K, Carrot-Zhang J, Hakimi AA, Schultz N, Ostrovnaya I, Gusev A, Jee J, Reznik E. Tang C, et al. Among authors: park t. Nat Genet. 2024 Nov;56(11):2318-2321. doi: 10.1038/s41588-024-01969-3. Epub 2024 Oct 28. Nat Genet. 2024. PMID: 39468367 Free PMC article.
5,498 results