Yao H - Search Results

1

Discovery of a Novel, Potent, Orally Active, and Safe Inhibitor Targeting Human Mitochondrial RNA Polymerase.

Li X, Ze X, Zhou S, Hu Z, He C, Jia Y, Liu L, Wang T, Li J, Xu S, Yang DH, Chen ZS, Yao H, Xu J, Yao H. Li X, et al. Among authors: yao h. J Med Chem. 2023 Apr 13;66(7):5118-5153. doi: 10.1021/acs.jmedchem.3c00058. Epub 2023 Mar 30. J Med Chem. 2023. PMID: 36997840

2

Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives.

Xu S, Li D, Pei L, Yao H, Wang C, Cai H, Yao H, Wu X, Xu J. Xu S, et al. Among authors: yao h. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2811-4. doi: 10.1016/j.bmcl.2014.04.119. Epub 2014 May 9. Bioorg Med Chem Lett. 2014. PMID: 24835198

3

Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives.

Xu S, Pei L, Li D, Yao H, Cai H, Yao H, Wu X, Xu J. Xu S, et al. Among authors: yao h. Fitoterapia. 2014 Dec;99:300-6. doi: 10.1016/j.fitote.2014.10.005. Epub 2014 Oct 12. Fitoterapia. 2014. PMID: 25316557

4

Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria.

Xu S, Luo S, Yao H, Cai H, Miao X, Wu F, Yang DH, Wu X, Xie W, Yao H, Chen ZS, Xu J. Xu S, et al. Among authors: yao h. J Med Chem. 2016 May 26;59(10):5022-34. doi: 10.1021/acs.jmedchem.6b00408. Epub 2016 Apr 27. J Med Chem. 2016. PMID: 27089099

5

Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies.

Xu S, Wang G, Lin Y, Zhang Y, Pei L, Yao H, Hu M, Qiu Y, Huang Z, Zhang Y, Xu J. Xu S, et al. Among authors: yao h. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2795-2800. doi: 10.1016/j.bmcl.2016.04.068. Epub 2016 Apr 24. Bioorg Med Chem Lett. 2016. PMID: 27158140

6

N-Heterocyclic Carbene Catalytic [4 + 2] Cyclization of 3-Alkylenyloxindoles with Enals: γ-Carbon Activation for Enantioselective Assembly of Spirocarbocyclic Oxindoles.

Yao H, Zhou Y, Chen X, Zhang P, Xu J, Liu H. Yao H, et al. J Org Chem. 2016 Oct 7;81(19):8888-8899. doi: 10.1021/acs.joc.6b01596. Epub 2016 Sep 22. J Org Chem. 2016. PMID: 27603177

7

The structural modification of natural products for novel drug discovery.

Yao H, Liu J, Xu S, Zhu Z, Xu J. Yao H, et al. Expert Opin Drug Discov. 2017 Feb;12(2):121-140. doi: 10.1080/17460441.2016.1272757. Epub 2016 Dec 22. Expert Opin Drug Discov. 2017. PMID: 28006993 Review.

8

A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.

Xu S, Yao H, Luo S, Zhang YK, Yang DH, Li D, Wang G, Hu M, Qiu Y, Wu X, Yao H, Xie W, Chen ZS, Xu J. Xu S, et al. Among authors: yao h. J Med Chem. 2017 Feb 23;60(4):1449-1468. doi: 10.1021/acs.jmedchem.6b01652. Epub 2017 Feb 13. J Med Chem. 2017. PMID: 28165738

9

Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation.

Xu S, Yao H, Pei L, Hu M, Li D, Qiu Y, Wang G, Wu L, Yao H, Zhu Z, Xu J. Xu S, et al. Among authors: yao h. Eur J Med Chem. 2017 May 26;132:310-321. doi: 10.1016/j.ejmech.2017.03.055. Epub 2017 Mar 25. Eur J Med Chem. 2017. PMID: 28395199 Free article.

10

6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents.

Xu S, Yao H, Hu M, Li D, Zhu Z, Xie W, Yao H, Wu L, Chen ZS, Xu J. Xu S, et al. Among authors: yao h. J Nat Prod. 2017 Sep 22;80(9):2391-2398. doi: 10.1021/acs.jnatprod.7b00057. Epub 2017 Sep 13. J Nat Prod. 2017. PMID: 28901767

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