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293 results

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Page 1
Negative allosteric modulation of the glucagon receptor by RAMP2.
Krishna Kumar K, O'Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK. Krishna Kumar K, et al. Among authors: kobilka bk. Cell. 2023 Mar 30;186(7):1465-1477.e18. doi: 10.1016/j.cell.2023.02.028. Cell. 2023. PMID: 37001505 Free PMC article.
Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy.
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, Che T, Hubbell WL, Kobilka BK, Chen C. Zhao J, et al. Among authors: kobilka bk. bioRxiv [Preprint]. 2023 Apr 29:2023.04.28.538657. doi: 10.1101/2023.04.28.538657. bioRxiv. 2023. Update in: Nature. 2024 May;629(8011):474-480. doi: 10.1038/s41586-024-07295-2. PMID: 37163120 Free PMC article. Updated. Preprint.
Step-wise activation of a Family C GPCR.
Kumar KK, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Kumar KK, et al. Among authors: kobilka bk. bioRxiv [Preprint]. 2023 Aug 30:2023.08.29.555158. doi: 10.1101/2023.08.29.555158. bioRxiv. 2023. PMID: 37693614 Free PMC article. Preprint.
Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt MF, Maul L, Pani B, Bahriz SM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch M, Kobilka BK. Casiraghi M, et al. Among authors: kobilka bk. bioRxiv [Preprint]. 2024 Apr 12:2024.03.28.587240. doi: 10.1101/2024.03.28.587240. bioRxiv. 2024. PMID: 38586060 Free PMC article. Preprint.
A µ-opioid receptor modulator that works cooperatively with naloxone.
O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK. O'Brien ES, et al. Among authors: kobilka bk. Nature. 2024 Jul;631(8021):686-693. doi: 10.1038/s41586-024-07587-7. Epub 2024 Jul 3. Nature. 2024. PMID: 38961287
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.
Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad A, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, Mathiesen JM, Liu X, Hildebrand PW. Batebi H, et al. Among authors: kobilka bk. Nat Struct Mol Biol. 2024 Jun 12. doi: 10.1038/s41594-024-01334-2. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38867113
Author Correction: Stepwise activation of a metabotropic glutamate receptor.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Krishna Kumar K, et al. Among authors: kobilka bk. Nature. 2024 May;629(8013):E13. doi: 10.1038/s41586-024-07470-5. Nature. 2024. PMID: 38702522 No abstract available.
Stepwise activation of a metabotropic glutamate receptor.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Krishna Kumar K, et al. Among authors: kobilka bk. Nature. 2024 May;629(8013):951-956. doi: 10.1038/s41586-024-07327-x. Epub 2024 Apr 17. Nature. 2024. PMID: 38632403
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C. Zhao J, et al. Among authors: kobilka bk. Nature. 2024 May;629(8011):474-480. doi: 10.1038/s41586-024-07295-2. Epub 2024 Apr 10. Nature. 2024. PMID: 38600384 Free PMC article.
Time-resolved cryo-EM of G-protein activation by a GPCR.
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Papasergi-Scott MM, et al. Among authors: kobilka bk. Nature. 2024 May;629(8014):1182-1191. doi: 10.1038/s41586-024-07153-1. Epub 2024 Mar 13. Nature. 2024. PMID: 38480881
293 results