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Page 1
Negative allosteric modulation of the glucagon receptor by RAMP2.
Krishna Kumar K, O'Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK. Krishna Kumar K, et al. Among authors: mathiesen jm. Cell. 2023 Mar 30;186(7):1465-1477.e18. doi: 10.1016/j.cell.2023.02.028. Cell. 2023. PMID: 37001505 Free PMC article.
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.
Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad A, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, Mathiesen JM, Liu X, Hildebrand PW. Batebi H, et al. Among authors: mathiesen jm. Nat Struct Mol Biol. 2024 Jun 12. doi: 10.1038/s41594-024-01334-2. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38867113
A µ-opioid receptor modulator that works cooperatively with naloxone.
O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK. O'Brien ES, et al. Among authors: mathiesen jm. Nature. 2024 Jul;631(8021):686-693. doi: 10.1038/s41586-024-07587-7. Epub 2024 Jul 3. Nature. 2024. PMID: 38961287
Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor.
He F, Wu CG, Gao Y, Rahman SN, Zaoralová M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G. He F, et al. Among authors: mathiesen jm. Nature. 2024 Feb;626(8001):1141-1148. doi: 10.1038/s41586-024-07055-2. Epub 2024 Feb 7. Nature. 2024. PMID: 38326620
Glycine: a long-sought novel ligand for GPR158.
Rosenkilde MM, Mathiesen JM. Rosenkilde MM, et al. Among authors: mathiesen jm. Trends Pharmacol Sci. 2023 Aug;44(8):489-491. doi: 10.1016/j.tips.2023.05.004. Epub 2023 Jun 13. Trends Pharmacol Sci. 2023. PMID: 37321907
Asymmetric activation of the calcium-sensing receptor homodimer.
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Bräuner-Osborne H, Mathiesen JM, Skiniotis G. Gao Y, et al. Among authors: mathiesen jm. Nature. 2021 Jul;595(7867):455-459. doi: 10.1038/s41586-021-03691-0. Epub 2021 Jun 30. Nature. 2021. PMID: 34194040 Free PMC article.
G-protein activation by a metabotropic glutamate receptor.
Seven AB, Barros-Álvarez X, de Lapeyrière M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G. Seven AB, et al. Among authors: mathiesen jm. Nature. 2021 Jul;595(7867):450-454. doi: 10.1038/s41586-021-03680-3. Epub 2021 Jun 30. Nature. 2021. PMID: 34194039 Free PMC article.
45 results