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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah K, Godes M, Perrimon N, Walensky LD. Leshchiner ES, et al. Among authors: luccarelli j. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1761-6. doi: 10.1073/pnas.1413185112. Epub 2015 Jan 26. Proc Natl Acad Sci U S A. 2015. PMID: 25624485 Free PMC article.
Allosteric sensitization of proapoptotic BAX.
Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Pritz JR, et al. Among authors: luccarelli j. Nat Chem Biol. 2017 Sep;13(9):961-967. doi: 10.1038/nchembio.2433. Epub 2017 Jul 10. Nat Chem Biol. 2017. PMID: 28692068 Free PMC article.
77 results