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Page 1
Multi-omic analysis reveals VEGFR2, PI3K, and JNK mediate the small molecule induction of human iPSC-derived cardiomyocyte proliferation.
Woo LA, Wintruba KL, Wissmann B, Tkachenko S, Kubicka E, Farber E, Engkvist O, Barrett I, Granberg KL, Plowright AT, Wolf MJ, Brautigan DL, Bekiranov S, Wang QD, Saucerman JJ. Woo LA, et al. Among authors: granberg kl. iScience. 2024 Jul 11;27(8):110485. doi: 10.1016/j.isci.2024.110485. eCollection 2024 Aug 16. iScience. 2024. PMID: 39171295 Free PMC article.
Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Granberg KL, Sakamaki S, Larsson N, Bergström F, Fuchigami R, Niwa Y, Ryberg E, Backmark A, Kato H, Miyazaki S, Iguchi K, Sakamoto T, Persson M, Idei A, Prieto Garcia L, Villar IC, Gradén H, Bergonzini G, Arvidsson T, Fujita T, Althage M, Ulander J, Kimura J, Yoneda H, Fjellström O, Mochida H, Lal M. Granberg KL, et al. J Med Chem. 2024 Mar 28;67(6):4419-4441. doi: 10.1021/acs.jmedchem.3c02184. Epub 2024 Mar 19. J Med Chem. 2024. PMID: 38502782
Mineralocorticoid Receptor Antagonists.
Nordqvist A, Granberg KL. Nordqvist A, et al. Among authors: granberg kl. Vitam Horm. 2019;109:151-188. doi: 10.1016/bs.vh.2018.10.008. Epub 2018 Dec 11. Vitam Horm. 2019. PMID: 30678854
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
Granberg KL, Yuan ZQ, Lindmark B, Edman K, Kajanus J, Hogner A, Malmgren M, O'Mahony G, Nordqvist A, Lindberg J, Tångefjord S, Kossenjans M, Löfberg C, Brånalt J, Liu D, Selmi N, Nikitidis G, Nordberg P, Hayen A, Aagaard A, Hansson E, Hermansson M, Ivarsson I, Jansson-Löfmark R, Karlsson U, Johansson U, William-Olsson L, Hartleib-Geschwindner J, Bamberg K. Granberg KL, et al. J Med Chem. 2019 Feb 14;62(3):1385-1406. doi: 10.1021/acs.jmedchem.8b01523. Epub 2019 Jan 30. J Med Chem. 2019. PMID: 30596500
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
Bamberg K, Johansson U, Edman K, William-Olsson L, Myhre S, Gunnarsson A, Geschwindner S, Aagaard A, Björnson Granqvist A, Jaisser F, Huang Y, Granberg KL, Jansson-Löfmark R, Hartleib-Geschwindner J. Bamberg K, et al. Among authors: granberg kl. PLoS One. 2018 Feb 23;13(2):e0193380. doi: 10.1371/journal.pone.0193380. eCollection 2018. PLoS One. 2018. PMID: 29474466 Free PMC article.
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