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Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination.
Stefanelli I, Corona A, Cerchia C, Cassese E, Improta S, Costanzi E, Pelliccia S, Morasso S, Esposito F, Paulis A, Scognamiglio S, Di Leva FS, Storici P, Brindisi M, Tramontano E, Cannalire R, Summa V. Stefanelli I, et al. Among authors: pelliccia s. Eur J Med Chem. 2023 May 5;253:115311. doi: 10.1016/j.ejmech.2023.115311. Epub 2023 Mar 31. Eur J Med Chem. 2023. PMID: 37043904 Free PMC article.
Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors.
La Pietra V, La Regina G, Coluccia A, Famiglini V, Pelliccia S, Plotkin B, Eldar-Finkelman H, Brancale A, Ballatore C, Crowe A, Brunden KR, Marinelli L, Novellino E, Silvestri R. La Pietra V, et al. Among authors: pelliccia s. J Med Chem. 2013 Dec 27;56(24):10066-78. doi: 10.1021/jm401466v. Epub 2013 Dec 11. J Med Chem. 2013. PMID: 24295046
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
Pelliccia S, Russomanno P, Barone S, Mateu B, Alfano AI, Miranda M, Coretti L, Lembo F, Piccolo M, Irace C, Friggeri L, Hargrove TY, Curtis A, Lepesheva GI, Kavanagh K, Buommino E, Brindisi M. Pelliccia S, et al. J Med Chem. 2024 Aug 22;67(16):14256-14276. doi: 10.1021/acs.jmedchem.4c01109. Epub 2024 Aug 8. J Med Chem. 2024. PMID: 39115219
65 results