Hanlon SP - Search Results

1

Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor.

Honda Malca S, Duss N, Meierhofer J, Patsch D, Niklaus M, Reiter S, Hanlon SP, Wetzl D, Kuhn B, Iding H, Buller R. Honda Malca S, et al. Among authors: hanlon sp. Commun Chem. 2024 Feb 28;7(1):46. doi: 10.1038/s42004-024-01130-5. Commun Chem. 2024. PMID: 38418529 Free PMC article.

2

Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.

Wang S, Ma S, Chen E, Wang J, Le H, Hanlon SP, Binder M, Lee W, Khojasteh SC, Salphati L. Wang S, et al. Among authors: hanlon sp. Drug Metab Dispos. 2023 Jul;51(7):862-872. doi: 10.1124/dmd.123.001289. Epub 2023 Apr 14. Drug Metab Dispos. 2023. PMID: 37059472

3

Screening methods for enzyme-mediated alcohol oxidation.

Contente ML, Marzuoli I, Iding H, Wetzl D, Puentener K, Hanlon SP, Paradisi F. Contente ML, et al. Among authors: hanlon sp. Sci Rep. 2022 Feb 22;12(1):3019. doi: 10.1038/s41598-022-07008-7. Sci Rep. 2022. PMID: 35194101 Free PMC article.

4

Human Enzymes for Organic Synthesis.

Winkler M, Geier M, Hanlon SP, Nidetzky B, Glieder A. Winkler M, et al. Among authors: hanlon sp. Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13406-13423. doi: 10.1002/anie.201800678. Epub 2018 Sep 11. Angew Chem Int Ed Engl. 2018. PMID: 29600541 Free PMC article. Review.

5

Amine Transaminase Engineering for Spatially Bulky Substrate Acceptance.

Weiß MS, Pavlidis IV, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT. Weiß MS, et al. Among authors: hanlon sp. Chembiochem. 2017 Jun 1;18(11):1022-1026. doi: 10.1002/cbic.201700033. Epub 2017 Apr 27. Chembiochem. 2017. PMID: 28334484

6

Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine.

Weiß MS, Pavlidis IV, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT. Weiß MS, et al. Among authors: hanlon sp. Org Biomol Chem. 2016 Nov 2;14(43):10249-10254. doi: 10.1039/c6ob02139e. Org Biomol Chem. 2016. PMID: 27739550

7

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines.

Pavlidis IV, Weiß MS, Genz M, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT. Pavlidis IV, et al. Among authors: hanlon sp. Nat Chem. 2016 Nov;8(11):1076-1082. doi: 10.1038/nchem.2578. Epub 2016 Jul 18. Nat Chem. 2016. PMID: 27768108

8

Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis.

Ferreira Antunes M, Eggimann FK, Kittelmann M, Lütz S, Hanlon SP, Wirz B, Bachler T, Winkler M. Ferreira Antunes M, et al. Among authors: hanlon sp. J Biotechnol. 2016 Oct 10;235:3-10. doi: 10.1016/j.jbiotec.2016.03.045. Epub 2016 Mar 25. J Biotechnol. 2016. PMID: 27021957 Review.

9

Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis.

Geier M, Bachler T, Hanlon SP, Eggimann FK, Kittelmann M, Weber H, Lütz S, Wirz B, Winkler M. Geier M, et al. Among authors: hanlon sp. Microb Cell Fact. 2015 Jun 12;14:82. doi: 10.1186/s12934-015-0262-0. Microb Cell Fact. 2015. PMID: 26062974 Free PMC article.

10

Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale.

Hanlon SP, Camattari A, Abad S, Glieder A, Kittelmann M, Lütz S, Wirz B, Winkler M. Hanlon SP, et al. Chem Commun (Camb). 2012 Jun 18;48(48):6001-3. doi: 10.1039/c2cc17878h. Epub 2012 May 10. Chem Commun (Camb). 2012. PMID: 22576266

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