Le H - Search Results

1

Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.

Wang S, Ma S, Chen E, Wang J, Le H, Hanlon SP, Binder M, Lee W, Khojasteh SC, Salphati L. Wang S, et al. Among authors: le h. Drug Metab Dispos. 2023 Jul;51(7):862-872. doi: 10.1124/dmd.123.001289. Epub 2023 Apr 14. Drug Metab Dispos. 2023. PMID: 37059472

2

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.

Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H. Liu L, et al. Among authors: le h. Drug Metab Dispos. 2011 Oct;39(10):1840-9. doi: 10.1124/dmd.111.040840. Epub 2011 Jul 8. Drug Metab Dispos. 2011. PMID: 21742900

3

Mechanistic studies of the cationic binding pocket of CYP2C9 in vitro and in silico: metabolism of nonionizable analogs of tienilic acid.

Tay S, Le H, Ford KA, Nelson SD, Khojasteh SC, Rademacher PM. Tay S, et al. Among authors: le h. Drug Metab Dispos. 2014 Nov;42(11):1955-63. doi: 10.1124/dmd.114.059022. Epub 2014 Sep 3. Drug Metab Dispos. 2014. PMID: 25187484

4

Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor.

Ma S, Suchomel J, Yanez E, Yost E, Liang X, Zhu R, Le H, Siebers N, Joas L, Morley R, Royer-Joo S, Pirzkall A, Salphati L, Ware JA, Morrissey KM. Ma S, et al. Among authors: le h. Br J Clin Pharmacol. 2019 Aug;85(8):1751-1760. doi: 10.1111/bcp.13961. Epub 2019 Jun 14. Br J Clin Pharmacol. 2019. PMID: 30973970 Free PMC article. Clinical Trial.

5

Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver.

Le H, Ford KA, Khojasteh SC, Fan PW. Le H, et al. Xenobiotica. 2013 Mar;43(3):236-45. doi: 10.3109/00498254.2012.715211. Epub 2012 Aug 30. Xenobiotica. 2013. PMID: 22931212

6

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.

Zhang C, Kenny JR, Le H, Deese A, Ford KA, Lightning LK, Fan PW, Driscoll JP, Halladay JS, Hop CE, Khojasteh SC. Zhang C, et al. Among authors: le h. Chem Res Toxicol. 2011 Oct 17;24(10):1668-77. doi: 10.1021/tx2002228. Epub 2011 Sep 25. Chem Res Toxicol. 2011. PMID: 21905702

7

Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.

Le H, Fan PW, Wong S, Ma S, Driscoll JP, Hop CE, Cyrus Khojasteh S. Le H, et al. Drug Metab Lett. 2016;10(2):136-43. doi: 10.2174/1872312810666160427104954. Drug Metab Lett. 2016. PMID: 27117606

8

Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.

Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis Phillips GD, Vollmar BS, Sadowsky JD, Vandlen R, Wei B, Su D, Fan P, Dragovich PS, Khojasteh SC, Hop CECA, Pillow TH. Zhang D, et al. Among authors: le h. Bioconjug Chem. 2018 Feb 21;29(2):267-274. doi: 10.1021/acs.bioconjchem.7b00576. Epub 2018 Feb 7. Bioconjug Chem. 2018. PMID: 29369629

9

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.

Staben ST, Siu M, Goldsmith R, Olivero AG, Do S, Burdick DJ, Heffron TP, Dotson J, Sutherlin DP, Zhu BY, Tsui V, Le H, Lee L, Lesnick J, Lewis C, Murray JM, Nonomiya J, Pang J, Prior WW, Salphati L, Rouge L, Sampath D, Sideris S, Wiesmann C, Wu P. Staben ST, et al. Among authors: le h. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4054-8. doi: 10.1016/j.bmcl.2011.04.124. Epub 2011 May 13. Bioorg Med Chem Lett. 2011. PMID: 21636270

10

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions.

Wong S, Doshi U, Vuong P, Liu N, Tay S, Le H, Kosaka M, Kenny JR, Li AP, Yan Z. Wong S, et al. Among authors: le h. Drug Metab Lett. 2018;12(1):3-13. doi: 10.2174/1872312812666171213114422. Drug Metab Lett. 2018. PMID: 29237391

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