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A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro.
Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn AHC, Zweckstetter M, Mandelkow E, Sticht H, Funke SA. Aillaud I, et al. Among authors: zweckstetter m. Alzheimers Res Ther. 2022 Jan 21;14(1):15. doi: 10.1186/s13195-022-00959-z. Alzheimers Res Ther. 2022. PMID: 35063014 Free PMC article.
Hsp multichaperone complex buffers pathologically modified Tau.
Moll A, Ramirez LM, Ninov M, Schwarz J, Urlaub H, Zweckstetter M. Moll A, et al. Among authors: zweckstetter m. Nat Commun. 2022 Jun 27;13(1):3668. doi: 10.1038/s41467-022-31396-z. Nat Commun. 2022. PMID: 35760815 Free PMC article.
Regulation of tau by peptidyl-prolyl isomerases.
Zhuang S, Chakraborty P, Zweckstetter M. Zhuang S, et al. Among authors: zweckstetter m. Curr Opin Struct Biol. 2024 Feb;84:102739. doi: 10.1016/j.sbi.2023.102739. Epub 2023 Dec 7. Curr Opin Struct Biol. 2024. PMID: 38061261 Free article. Review.
Charge-induced molecular alignment of intrinsically disordered proteins.
Skora L, Cho MK, Kim HY, Becker S, Fernandez CO, Blackledge M, Zweckstetter M. Skora L, et al. Among authors: zweckstetter m. Angew Chem Int Ed Engl. 2006 Oct 27;45(42):7012-5. doi: 10.1002/anie.200602317. Angew Chem Int Ed Engl. 2006. PMID: 17009286 No abstract available.
294 results