Jacobs S - Search Results

1

"Stapling" scFv for multispecific biotherapeutics of superior properties.

Boucher LE, Prinslow EG, Feldkamp M, Yi F, Nanjunda R, Wu SJ, Liu T, Lacy ER, Jacobs S, Kozlyuk N, Del Rosario B, Wu B, Aquino P, Davidson RC, Heyne S, Mazzanti N, Testa J, Diem MD, Gorre E, Mahan A, Nanda H, Gunawardena HP, Gervais A, Armstrong AA, Teplyakov A, Huang C, Zwolak A, Chowdhury P, Cheung WC, Luo J. Boucher LE, et al. Among authors: jacobs s. MAbs. 2023 Jan-Dec;15(1):2195517. doi: 10.1080/19420862.2023.2195517. MAbs. 2023. PMID: 37074212 Free PMC article.

2

Mechanisms of self-association of a human monoclonal antibody CNTO607.

Bethea D, Wu SJ, Luo J, Hyun L, Lacy ER, Teplyakov A, Jacobs SA, O'Neil KT, Gilliland GL, Feng Y. Bethea D, et al. Protein Eng Des Sel. 2012 Oct;25(10):531-7. doi: 10.1093/protein/gzs047. Epub 2012 Aug 22. Protein Eng Des Sel. 2012. PMID: 22915597

3

Design of novel FN3 domains with high stability by a consensus sequence approach.

Jacobs SA, Diem MD, Luo J, Teplyakov A, Obmolova G, Malia T, Gilliland GL, O'Neil KT. Jacobs SA, et al. Protein Eng Des Sel. 2012 Mar;25(3):107-17. doi: 10.1093/protein/gzr064. Epub 2012 Jan 12. Protein Eng Des Sel. 2012. PMID: 22240293

4

Surface salt bridges contribute to the extreme thermal stability of an FN3-like domain from a thermophilic bacterium.

Boucher L, Somani S, Negron C, Ma W, Jacobs S, Chan W, Malia T, Obmolova G, Teplyakov A, Gilliland GL, Luo J. Boucher L, et al. Among authors: jacobs s. Proteins. 2022 Jan;90(1):270-281. doi: 10.1002/prot.26218. Epub 2021 Oct 11. Proteins. 2022. PMID: 34405904

5

Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.

Diem MD, Hyun L, Yi F, Hippensteel R, Kuhar E, Lowenstein C, Swift EJ, O'Neil KT, Jacobs SA. Diem MD, et al. Protein Eng Des Sel. 2014 Oct;27(10):419-29. doi: 10.1093/protein/gzu016. Epub 2014 Apr 30. Protein Eng Des Sel. 2014. PMID: 24786107

6

C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffold.

Teplyakov A, Obmolova G, Malia TJ, Luo J, Jacobs SA, Chan W, Domingo D, Baker A, O'Neil KT, Gilliland GL. Teplyakov A, et al. Proteins. 2014 Jul;82(7):1359-69. doi: 10.1002/prot.24502. Epub 2014 Feb 12. Proteins. 2014. PMID: 24375666

7

Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.

Obmolova G, Teplyakov A, Malia TJ, Keough E, Luo J, Sweet R, Jacobs SA, Yi F, Hippensteel R, O'Neil KT, Gilliland GL. Obmolova G, et al. Proteins. 2015 Jun;83(6):1191-7. doi: 10.1002/prot.24815. Epub 2015 May 8. Proteins. 2015. PMID: 25900776 Free PMC article.

8

N-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions.

Luo J, Teplyakov A, Obmolova G, Malia TJ, Chan W, Jacobs SA, O'Neil KT, Gilliland GL. Luo J, et al. Proteins. 2014 Jul;82(7):1527-33. doi: 10.1002/prot.24517. Epub 2014 Feb 18. Proteins. 2014. PMID: 24464739

9

Conformational flexibility of an anti-IL-13 DARPin†.

Teplyakov A, Malia TJ, Obmolova G, Jacobs SA, O'Neil KT, Gilliland GL. Teplyakov A, et al. Protein Eng Des Sel. 2017 Jan;30(1):31-37. doi: 10.1093/protein/gzw059. Epub 2016 Nov 23. Protein Eng Des Sel. 2017. PMID: 27881684

10

Structure-based engineering of a monoclonal antibody for improved solubility.

Wu SJ, Luo J, O'Neil KT, Kang J, Lacy ER, Canziani G, Baker A, Huang M, Tang QM, Raju TS, Jacobs SA, Teplyakov A, Gilliland GL, Feng Y. Wu SJ, et al. Protein Eng Des Sel. 2010 Aug;23(8):643-51. doi: 10.1093/protein/gzq037. Epub 2010 Jun 11. Protein Eng Des Sel. 2010. PMID: 20543007

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