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R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.
Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B. Mendoza P, et al. Among authors: alarcon b. Sci Signal. 2018 May 29;11(532):eaal1506. doi: 10.1126/scisignal.aal1506. Sci Signal. 2018. PMID: 29844052
Antigen phagocytosis by B cells is required for a potent humoral response.
Martínez-Riaño A, Bovolenta ER, Mendoza P, Oeste CL, Martín-Bermejo MJ, Bovolenta P, Turner M, Martínez-Martín N, Alarcón B. Martínez-Riaño A, et al. Among authors: alarcon b. EMBO Rep. 2018 Sep;19(9):e46016. doi: 10.15252/embr.201846016. Epub 2018 Jul 9. EMBO Rep. 2018. PMID: 29987136 Free PMC article.
Editorial: Nck has a knack for T cell differentiation.
Oeste CL, Alarcón B. Oeste CL, et al. Among authors: alarcon b. J Leukoc Biol. 2015 Sep;98(3):297-8. doi: 10.1189/jlb.2CE0415-181R. J Leukoc Biol. 2015. PMID: 26329897 Free article. No abstract available.
Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.
Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, Veiga E. Cruz-Adalia A, et al. Among authors: alarcon b. Nat Commun. 2017 Nov 17;8(1):1591. doi: 10.1038/s41467-017-01661-7. Nat Commun. 2017. PMID: 29147022 Free PMC article.
A window of opportunity for cooperativity in the T Cell Receptor.
Martin-Blanco N, Blanco R, Alda-Catalinas C, Bovolenta ER, Oeste CL, Palmer E, Schamel WW, Lythe G, Molina-París C, Castro M, Alarcon B. Martin-Blanco N, et al. Among authors: alarcon b. Nat Commun. 2018 Jul 5;9(1):2618. doi: 10.1038/s41467-018-05050-6. Nat Commun. 2018. PMID: 29976994 Free PMC article.
RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.
Martínez-Riaño A, Bovolenta ER, Boccasavia VL, Ponomarenko J, Abia D, Oeste CL, Fresno M, van Santen HM, Alarcon B. Martínez-Riaño A, et al. Among authors: alarcon b. J Exp Med. 2019 Oct 7;216(10):2427-2447. doi: 10.1084/jem.20181959. Epub 2019 Jul 19. J Exp Med. 2019. PMID: 31324740 Free PMC article.
Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
Hortal AM, Oeste CL, Cifuentes C, Alcoceba M, Fernández-Pisonero I, Clavaín L, Tercero R, Mendoza P, Domínguez V, García-Flores M, Pintado B, Abia D, García-Macías C, Navarro-Bailón A, Bustelo XR, González M, Alarcón B. Hortal AM, et al. Among authors: alarcon b. Mol Cancer. 2022 Feb 4;21(1):35. doi: 10.1186/s12943-022-01496-x. Mol Cancer. 2022. PMID: 35120522 Free PMC article.
188 results