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Page 1
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.
Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, Axtman AD. Ong HW, et al. Among authors: silvaroli ja. ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. doi: 10.1021/acschemneuro.3c00135. Epub 2023 Apr 21. ACS Chem Neurosci. 2023. PMID: 37084253 Free PMC article.
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir SK, Axtman AD. Castano A, et al. Among authors: silvaroli ja. Elife. 2023 Jul 25;12:e88206. doi: 10.7554/eLife.88206. Elife. 2023. PMID: 37490324 Free PMC article.
Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury.
Kim JY, Silvaroli JA, Martinez GV, Bisunke B, Luna Ramirez AV, Jayne LA, Feng MJHH, Girotra B, Acosta Martinez SM, Vermillion CR, Karel IZ, Ferrell N, Weisleder N, Chung S, Christman JW, Brooks CR, Madhavan SM, Hoyt KR, Cianciolo RE, Satoskar AA, Zepeda-Orozco D, Sullivan JC, Davidson AJ, Bajwa A, Pabla NS. Kim JY, et al. Among authors: silvaroli ja. Kidney Int. 2023 Jun;103(6):1093-1104. doi: 10.1016/j.kint.2023.02.026. Epub 2023 Mar 13. Kidney Int. 2023. PMID: 36921719 Free PMC article.
Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen.
Drabison T, Boeckman M, Yang Y, Huang KM, de Bruijn P, Nepal MR, Silvaroli JA, Chowdhury AT, Eisenmann ED, Cheng X, Pabla N, Mathijssen RHJ, Baker SD, Hu S, Sparreboom A, Talebi Z. Drabison T, et al. Among authors: silvaroli ja. Cancer Res Commun. 2024 Sep 1;4(9):2489-2497. doi: 10.1158/2767-9764.CRC-24-0332. Cancer Res Commun. 2024. PMID: 39207193 Free PMC article.
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
Bashore FM, Min SM, Chen X, Howell S, Rinderle CH, Morel G, Silvaroli JA, Wells CI, Bunnell BA, Drewry DH, Pabla NS, Ultanir SK, Bullock AN, Axtman AD. Bashore FM, et al. Among authors: silvaroli ja. ACS Med Chem Lett. 2024 Jul 3;15(8):1325-1333. doi: 10.1021/acsmedchemlett.4c00219. eCollection 2024 Aug 8. ACS Med Chem Lett. 2024. PMID: 39140040 Free PMC article.
Role of the CDKL1-SOX11 signaling axis in acute kidney injury.
Silvaroli JA, Martinez GV, Vanichapol T, Davidson AJ, Zepeda-Orozco D, Pabla NS, Kim JY. Silvaroli JA, et al. Am J Physiol Renal Physiol. 2024 Sep 1;327(3):F426-F434. doi: 10.1152/ajprenal.00147.2024. Epub 2024 Jul 11. Am J Physiol Renal Physiol. 2024. PMID: 38991010
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
Bashore FM, Min SM, Chen X, Howell S, Rinderle CH, Morel G, Silvaroli JA, Wells CI, Bunnell BA, Drewry DH, Pabla NS, Ultanir SK, Bullock AN, Axtman AD. Bashore FM, et al. Among authors: silvaroli ja. bioRxiv [Preprint]. 2024 May 14:2024.05.12.593776. doi: 10.1101/2024.05.12.593776. bioRxiv. 2024. Update in: ACS Med Chem Lett. 2024 Jul 03;15(8):1325-1333. doi: 10.1021/acsmedchemlett.4c00219 PMID: 38798634 Free PMC article. Updated. Preprint.
Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31.
Silvaroli JA, Bisunke B, Kim JY, Stayton A, Jayne LA, Martinez SA, Nguyen C, Patel PS, Vanichapol T, Verma V, Akhter J, Bolisetty S, Madhavan SM, Kuscu C, Coss CC, Zepeda-Orozco D, Parikh SV, Satoskar AA, Davidson AJ, Eason JD, Szeto HH, Pabla NS, Bajwa A. Silvaroli JA, et al. J Am Soc Nephrol. 2024 Jun 1;35(6):681-695. doi: 10.1681/ASN.0000000000000338. Epub 2024 Mar 26. J Am Soc Nephrol. 2024. PMID: 38530359
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir S, Axtman AD. Castano A, et al. Among authors: silvaroli ja. bioRxiv [Preprint]. 2023 Jun 16:2023.04.24.538049. doi: 10.1101/2023.04.24.538049. bioRxiv. 2023. Update in: Elife. 2023 Jul 25;12:e88206. doi: 10.7554/eLife.88206 PMID: 37162893 Free PMC article. Updated. Preprint.
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective.
Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, Axtman AD. Ong HW, et al. Among authors: silvaroli ja. bioRxiv [Preprint]. 2023 Feb 10:2023.02.09.527935. doi: 10.1101/2023.02.09.527935. bioRxiv. 2023. Update in: ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. doi: 10.1021/acschemneuro.3c00135 PMID: 36798313 Free PMC article. Updated. Preprint.
22 results