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Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain.
Harris NJ, Jenkins ML, Nam SE, Rathinaswamy MK, Parson MA, Ranga-Prasad H, Dalwadi U, Moeller BE, Sheekey E, Hansen SD, Yip CK, Burke JE. Harris NJ, et al. Among authors: sheekey e. bioRxiv [Preprint]. 2023 May 23:2023.04.12.536585. doi: 10.1101/2023.04.12.536585. bioRxiv. 2023. Update in: Elife. 2023 Jul 07;12:RP88058. doi: 10.7554/eLife.88058 PMID: 37090531 Free PMC article. Updated. Preprint.
Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF.
Rodríguez-Molina JB, O'Reilly FJ, Fagarasan H, Sheekey E, Maslen S, Skehel JM, Rappsilber J, Passmore LA. Rodríguez-Molina JB, et al. Among authors: sheekey e. Mol Cell. 2022 Jul 7;82(13):2490-2504.e12. doi: 10.1016/j.molcel.2022.04.021. Epub 2022 May 17. Mol Cell. 2022. PMID: 35584695 Free PMC article.
p53 in senescence - it's a marathon, not a sprint.
Sheekey E, Narita M. Sheekey E, et al. FEBS J. 2023 Mar;290(5):1212-1220. doi: 10.1111/febs.16325. Epub 2021 Dec 26. FEBS J. 2023. PMID: 34921507 Free article. Review.