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Page 1
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.
Sasaki L, Hamada Y, Yarimizu D, Suzuki T, Nakamura H, Shimada A, Pham KTN, Shao X, Yamamura K, Inatomi T, Morinaga H, Nishimura EK, Kudo F, Manabe I, Haraguchi S, Sugiura Y, Suematsu M, Kinoshita S, Machida M, Nakajima T, Kiyonari H, Okamura H, Yamaguchi Y, Miyake T, Doi M. Sasaki L, et al. Among authors: kiyonari h. Nat Aging. 2022 Feb;2(2):105-114. doi: 10.1038/s43587-021-00167-8. Epub 2022 Feb 10. Nat Aging. 2022. PMID: 37117756 Free PMC article.
Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice.
Sassa T, Tadaki M, Kiyonari H, Kihara A. Sassa T, et al. Among authors: kiyonari h. FASEB J. 2018 Jun;32(6):2966-2978. doi: 10.1096/fj.201700947R. Epub 2018 Jan 17. FASEB J. 2018. PMID: 29401594
Thus, in addition to the well-known VLC ceramides (acylceramides) in the epidermis, VLC meibum lipids are barrier-forming lipids.-Sassa, T., Tadaki, M., Kiyonari, H., Kihara, A. Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye …
Thus, in addition to the well-known VLC ceramides (acylceramides) in the epidermis, VLC meibum lipids are barrier-forming lipids.-Sassa, T., …
Tracing the origin of hair follicle stem cells.
Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H. Morita R, et al. Among authors: kiyonari h. Nature. 2021 Jun;594(7864):547-552. doi: 10.1038/s41586-021-03638-5. Epub 2021 Jun 9. Nature. 2021. PMID: 34108685
Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles.
Wang Y, Cao S, Tone D, Fujishima H, Yamada RG, Ohno RI, Shi S, Matsuzawa K, Yada S, Kaneko M, Sakamoto H, Onishi T, Ukai-Tadenuma M, Ukai H, Hanashima C, Hirose K, Kiyonari H, Sumiyama K, Ode KL, Ueda HR. Wang Y, et al. Among authors: kiyonari h. Nature. 2024 Dec;636(8042):412-421. doi: 10.1038/s41586-024-08132-2. Epub 2024 Nov 6. Nature. 2024. PMID: 39506111
Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.
Dong B, Hiasa M, Higa Y, Ohnishi Y, Endo I, Kondo T, Takashi Y, Tsoumpra M, Kainuma R, Sawatsubashi S, Kiyonari H, Shioi G, Sakaue H, Nakashima T, Kato S, Abe M, Fukumoto S, Matsumoto T. Dong B, et al. Among authors: kiyonari h. Nat Commun. 2022 Nov 23;13(1):7194. doi: 10.1038/s41467-022-34869-3. Nat Commun. 2022. PMID: 36424386 Free PMC article.
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.
Kon K, Ode KL, Mano T, Fujishima H, Takahashi RR, Tone D, Shimizu C, Shiono S, Yada S, Matsuzawa K, Yoshida SY, Yoshida Garçon J, Kaneko M, Shinohara Y, Yamada RG, Shi S, Miyamichi K, Sumiyama K, Kiyonari H, Susaki EA, Ueda HR. Kon K, et al. Among authors: kiyonari h. Nat Commun. 2024 Jul 18;15(1):6054. doi: 10.1038/s41467-024-50168-5. Nat Commun. 2024. PMID: 39025867 Free PMC article.
289 results