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Development of pyrolo[2,3-c]pyrazole, pyrolo[2,3-d]pyrimidine and their bioisosteres as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological evaluation and molecular dynamics investigations.
Azmy EM, Hagras M, Ewida MA, Doghish AS, Gamil Khidr E, El-Husseiny AA, Gomaa MH, Refaat HM, Ismail NSM, Nassar IF, Lashin WH. Azmy EM, et al. Among authors: lashin wh. Bioorg Chem. 2023 Oct;139:106729. doi: 10.1016/j.bioorg.2023.106729. Epub 2023 Jul 13. Bioorg Chem. 2023. PMID: 37467621