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Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model.
Spatz P, Steinmüller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M. Spatz P, et al. Among authors: maurice t. J Med Chem. 2023 May 11;66(9):6414-6435. doi: 10.1021/acs.jmedchem.3c00541. Epub 2023 Apr 26. J Med Chem. 2023. PMID: 37127287 Free PMC article.
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.
Dolles D, Hoffmann M, Gunesch S, Marinelli O, Möller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M. Dolles D, et al. Among authors: maurice t. J Med Chem. 2018 Feb 22;61(4):1646-1663. doi: 10.1021/acs.jmedchem.7b01760. Epub 2018 Feb 5. J Med Chem. 2018. PMID: 29400965
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.
Hoffmann M, Stiller C, Endres E, Scheiner M, Gunesch S, Sotriffer C, Maurice T, Decker M. Hoffmann M, et al. Among authors: maurice t. J Med Chem. 2019 Oct 24;62(20):9116-9140. doi: 10.1021/acs.jmedchem.9b01012. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31609115
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.
Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hübner H, Gmeiner P, Maitra R, Maurice T, Decker M. Scheiner M, et al. Among authors: maurice t. J Med Chem. 2019 Oct 24;62(20):9078-9102. doi: 10.1021/acs.jmedchem.9b00623. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31609608 Free PMC article.
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.
He F, Chou CJ, Scheiner M, Poeta E, Yuan Chen N, Gunesch S, Hoffmann M, Sotriffer C, Monti B, Maurice T, Decker M. He F, et al. Among authors: maurice t. J Med Chem. 2021 Apr 8;64(7):3794-3812. doi: 10.1021/acs.jmedchem.0c01940. Epub 2021 Mar 26. J Med Chem. 2021. PMID: 33769811
Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model.
Scheiner M, Hoffmann M, He F, Poeta E, Chatonnet A, Monti B, Maurice T, Decker M. Scheiner M, et al. Among authors: maurice t. J Med Chem. 2021 Jul 8;64(13):9302-9320. doi: 10.1021/acs.jmedchem.1c00534. Epub 2021 Jun 21. J Med Chem. 2021. PMID: 34152756
Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation.
Scheiner M, Sink A, Hoffmann M, Vrigneau C, Endres E, Carles A, Sotriffer C, Maurice T, Decker M. Scheiner M, et al. Among authors: maurice t. J Am Chem Soc. 2022 Feb 23;144(7):3279-3284. doi: 10.1021/jacs.1c13492. Epub 2022 Feb 9. J Am Chem Soc. 2022. PMID: 35138833
215 results