Zhang H - Search Results

1

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT.

Al Khatib I, Deng J, Lei Y, Torres-Odio S, Rojas GR, Newman LE, Chung BK, Symes A, Zhang H, Huang SN, Pommier Y, Khan A, Shadel GS, West AP, Gibson WT, Shutt TE. Al Khatib I, et al. Among authors: zhang h. Hum Mol Genet. 2023 Jul 20;32(15):2422-2440. doi: 10.1093/hmg/ddad062. Hum Mol Genet. 2023. PMID: 37129502 Free PMC article.

2

Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome.

Al Khatib I, Deng J, Symes A, Kerr M, Zhang H, Huang SN, Pommier Y, Khan A, Shutt TE. Al Khatib I, et al. Among authors: zhang h. J Biol Chem. 2022 Oct;298(10):102420. doi: 10.1016/j.jbc.2022.102420. Epub 2022 Aug 24. J Biol Chem. 2022. PMID: 36030054 Free PMC article.

3

Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA.

Zhang H, Pommier Y. Zhang H, et al. Biochemistry. 2008 Oct 28;47(43):11196-203. doi: 10.1021/bi800774b. Epub 2008 Oct 1. Biochemistry. 2008. PMID: 18826252 Free PMC article.

4

Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene.

Zhang H, Meng LH, Pommier Y. Zhang H, et al. Biochimie. 2007 Apr;89(4):474-81. doi: 10.1016/j.biochi.2006.11.002. Epub 2006 Nov 27. Biochimie. 2007. PMID: 17161897 Review.

5

Mapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).

Dalla Rosa I, Huang SY, Agama K, Khiati S, Zhang H, Pommier Y. Dalla Rosa I, et al. Among authors: zhang h. J Biol Chem. 2014 Jun 27;289(26):18595-602. doi: 10.1074/jbc.M114.555367. Epub 2014 May 5. J Biol Chem. 2014. PMID: 24798329 Free PMC article.

6

Poisoning of mitochondrial topoisomerase I by lamellarin D.

Khiati S, Seol Y, Agama K, Dalla Rosa I, Agrawal S, Fesen K, Zhang H, Neuman KC, Pommier Y. Khiati S, et al. Among authors: zhang h. Mol Pharmacol. 2014 Aug;86(2):193-9. doi: 10.1124/mol.114.092833. Epub 2014 Jun 2. Mol Pharmacol. 2014. PMID: 24890608 Free PMC article.

7

Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription.

Dalla Rosa I, Zhang H, Khiati S, Wu X, Pommier Y. Dalla Rosa I, et al. Among authors: zhang h. J Biol Chem. 2017 Dec 8;292(49):20162-20172. doi: 10.1074/jbc.M117.815241. Epub 2017 Oct 11. J Biol Chem. 2017. PMID: 29021209 Free PMC article.

8

Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity.

Khiati S, Dalla Rosa I, Sourbier C, Ma X, Rao VA, Neckers LM, Zhang H, Pommier Y. Khiati S, et al. Among authors: zhang h. Clin Cancer Res. 2014 Sep 15;20(18):4873-81. doi: 10.1158/1078-0432.CCR-13-3373. Epub 2014 Apr 8. Clin Cancer Res. 2014. PMID: 24714774 Free PMC article.

9

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.

Zhang H, Zhang YW, Yasukawa T, Dalla Rosa I, Khiati S, Pommier Y. Zhang H, et al. Among authors: zhang yw. Nucleic Acids Res. 2014 Jun;42(11):7259-67. doi: 10.1093/nar/gku384. Epub 2014 May 6. Nucleic Acids Res. 2014. PMID: 24803675 Free PMC article.

10

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.

Khiati S, Baechler SA, Factor VM, Zhang H, Huang SY, Dalla Rosa I, Sourbier C, Neckers L, Thorgeirsson SS, Pommier Y. Khiati S, et al. Among authors: zhang h. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11282-7. doi: 10.1073/pnas.1511016112. Epub 2015 Aug 24. Proc Natl Acad Sci U S A. 2015. PMID: 26305952 Free PMC article.

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