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Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer.
Bennett CN, Tomlinson CC, Michalowski AM, Chu IM, Luger D, Mittereder LR, Aprelikova O, Shou J, Piwinica-Worms H, Caplen NJ, Hollingshead MG, Green JE. Bennett CN, et al. Among authors: caplen nj. Breast Cancer Res. 2012 Jul 19;14(4):R109. doi: 10.1186/bcr3230. Breast Cancer Res. 2012. PMID: 22812567 Free PMC article.
Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.
Marino N, Collins JW, Shen C, Caplen NJ, Merchant AS, Gökmen-Polar Y, Goswami CP, Hoshino T, Qian Y, Sledge GW Jr, Steeg PS. Marino N, et al. Among authors: caplen nj. Clin Exp Metastasis. 2014 Oct;31(7):771-86. doi: 10.1007/s10585-014-9667-0. Epub 2014 Aug 3. Clin Exp Metastasis. 2014. PMID: 25086928 Free PMC article.
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN. Lorenzi PL, et al. Among authors: caplen nj. Mol Cancer Ther. 2006 Nov;5(11):2613-23. doi: 10.1158/1535-7163.MCT-06-0447. Epub 2006 Nov 6. Mol Cancer Ther. 2006. PMID: 17088436
ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3.
Ebegboni VJ, Jones TL, Brownmiller T, Zhao PX, Pehrsson EC, Rajan SS, Caplen NJ. Ebegboni VJ, et al. Among authors: caplen nj. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572864. doi: 10.1101/2023.12.21.572864. bioRxiv. 2023. Update in: Mol Cancer Res. 2024 Jul 2;22(7):625-641. doi: 10.1158/1541-7786.MCR-23-1090 PMID: 38187702 Free PMC article. Updated. Preprint.
82 results