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The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease.
Belcher JD, Nataraja S, Abdulla F, Zhang P, Chen C, Nguyen J, Ruan C, Singh M, Demes S, Olson L, Stickens D, Stanwix J, Clarke E, Huang Y, Biddle M, Vercellotti GM. Belcher JD, et al. Among authors: zhang p. Front Med (Lausanne). 2023 Apr 18;10:1101501. doi: 10.3389/fmed.2023.1101501. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37144034 Free PMC article.
Identification of a Heme Activation Site on the MD-2/TLR4 Complex.
Belcher JD, Zhang P, Nguyen J, Kiser ZM, Nath KA, Hu J, Trent JO, Vercellotti GM. Belcher JD, et al. Among authors: zhang p. Front Immunol. 2020 Jun 30;11:1370. doi: 10.3389/fimmu.2020.01370. eCollection 2020. Front Immunol. 2020. PMID: 32695117 Free PMC article.
Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease.
Beckman JD, Abdullah F, Chen C, Kirchner R, Rivera-Rodriguez D, Kiser ZM, Nguyen A, Zhang P, Nguyen J, Hebbel RP, Belcher JD, Vercellotti GM. Beckman JD, et al. Among authors: zhang p. Front Immunol. 2021 Jan 19;11:613278. doi: 10.3389/fimmu.2020.613278. eCollection 2020. Front Immunol. 2021. PMID: 33542720 Free PMC article.
Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence.
Gentinetta T, Belcher JD, Brügger-Verdon V, Adam J, Ruthsatz T, Bain J, Schu D, Ventrici L, Edler M, Lioe H, Patel K, Chen C, Nguyen J, Abdulla F, Zhang P, Wassmer A, Jain M, Mischnik M, Pelzing M, Martin K, Davis R, Didichenko S, Schaub A, Brinkman N, Herzog E, Zürcher A, Vercellotti GM, Kato GJ, Höbarth G. Gentinetta T, et al. Among authors: zhang p. J Clin Med. 2022 Jan 26;11(3):630. doi: 10.3390/jcm11030630. J Clin Med. 2022. PMID: 35160081 Free PMC article.
Oxidative stress regulates left ventricular PDE5 expression in the failing heart.
Lu Z, Xu X, Hu X, Lee S, Traverse JH, Zhu G, Fassett J, Tao Y, Zhang P, dos Remedios C, Pritzker M, Hall JL, Garry DJ, Chen Y. Lu Z, et al. Among authors: zhang p. Circulation. 2010 Apr 6;121(13):1474-83. doi: 10.1161/CIRCULATIONAHA.109.906818. Epub 2010 Mar 22. Circulation. 2010. PMID: 20308615 Free PMC article.
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