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STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy.
Wang-Bishop L, Kimmel BR, Ngwa VM, Madden MZ, Baljon JJ, Florian DC, Hanna A, Pastora LE, Sheehy TL, Kwiatkowski AJ, Wehbe M, Wen X, Becker KW, Garland KM, Schulman JA, Shae D, Edwards D, Wolf MM, Delapp R, Christov PP, Beckermann KE, Balko JM, Rathmell WK, Rathmell JC, Chen J, Wilson JT. Wang-Bishop L, et al. Among authors: rathmell jc, rathmell wk. Sci Immunol. 2023 May 12;8(83):eadd1153. doi: 10.1126/sciimmunol.add1153. Epub 2023 May 5. Sci Immunol. 2023. PMID: 37146128 Free PMC article.
HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. Arreola A, et al. Among authors: rathmell jc, rathmell wk. PLoS One. 2014 May 30;9(5):e98705. doi: 10.1371/journal.pone.0098705. eCollection 2014. PLoS One. 2014. PMID: 24879016 Free PMC article.
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. Kishton RJ, et al. Among authors: rathmell jc, rathmell wk. Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008. Cell Metab. 2016. PMID: 27076078 Free PMC article.
Dysfunctional T cell metabolism in the tumor microenvironment.
Beckermann KE, Dudzinski SO, Rathmell JC. Beckermann KE, et al. Among authors: rathmell jc. Cytokine Growth Factor Rev. 2017 Jun;35:7-14. doi: 10.1016/j.cytogfr.2017.04.003. Epub 2017 Apr 23. Cytokine Growth Factor Rev. 2017. PMID: 28456467 Free PMC article. Review.
Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling.
Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, Johnson DB. Siska PJ, et al. Among authors: rathmell jc, rathmell wk. Oncoimmunology. 2017 Mar 20;6(4):e1305535. doi: 10.1080/2162402X.2017.1305535. eCollection 2017. Oncoimmunology. 2017. PMID: 28507813 Free PMC article.
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Siska PJ, et al. Among authors: rathmell jc, rathmell wk. JCI Insight. 2017 Jun 15;2(12):e93411. doi: 10.1172/jci.insight.93411. eCollection 2017 Jun 15. JCI Insight. 2017. PMID: 28614802 Free PMC article.
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL. Lee KM, et al. Among authors: rathmell jc. Cell Metab. 2017 Oct 3;26(4):633-647.e7. doi: 10.1016/j.cmet.2017.09.009. Cell Metab. 2017. PMID: 28978427 Free PMC article.
Metabolic Barriers to T Cell Function in Tumors.
Sugiura A, Rathmell JC. Sugiura A, et al. Among authors: rathmell jc. J Immunol. 2018 Jan 15;200(2):400-407. doi: 10.4049/jimmunol.1701041. J Immunol. 2018. PMID: 29311381 Free PMC article. Review.
Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.
Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, Luevano LA, Wolf M, Baliga U, Krieg C, Beeson CC, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, Mehrotra S. Chatterjee S, et al. Among authors: rathmell jc. Clin Cancer Res. 2019 Feb 1;25(3):1036-1049. doi: 10.1158/1078-0432.CCR-18-0706. Epub 2018 Oct 16. Clin Cancer Res. 2019. PMID: 30327305 Free PMC article.
233 results