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PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.
Frkic RL, Pederick JL, Horsfall AJ, Jovcevski B, Crame EE, Kowalczyk W, Pukala TL, Chang MR, Zheng J, Blayo AL, Abell AD, Kamenecka TM, Harbort JS, Harmer JR, Griffin PR, Bruning JB. Frkic RL, et al. Among authors: abell ad. ACS Chem Biol. 2023 May 19;18(5):1115-1123. doi: 10.1021/acschembio.2c00917. Epub 2023 May 5. ACS Chem Biol. 2023. PMID: 37146157
Macrocyclic protease inhibitors with reduced peptide character.
Chua KC, Pietsch M, Zhang X, Hautmann S, Chan HY, Bruning JB, Gütschow M, Abell AD. Chua KC, et al. Among authors: abell ad. Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7828-31. doi: 10.1002/anie.201404301. Epub 2014 Jun 5. Angew Chem Int Ed Engl. 2014. PMID: 24903745
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.
Frkic RL, He Y, Rodriguez BB, Chang MR, Kuruvilla D, Ciesla A, Abell AD, Kamenecka TM, Griffin PR, Bruning JB. Frkic RL, et al. Among authors: abell ad. J Med Chem. 2017 Jun 8;60(11):4584-4593. doi: 10.1021/acs.jmedchem.6b01727. Epub 2017 May 22. J Med Chem. 2017. PMID: 28485590 Free PMC article.
Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.
Lee KJ, Tieu W, Blanco-Rodriguez B, Paparella AS, Yu J, Hayes A, Feng J, Marshall AC, Noll B, Milne R, Cini D, Wilce MCJ, Booker GW, Bruning JB, Polyak SW, Abell AD. Lee KJ, et al. Among authors: abell ad. ACS Chem Biol. 2019 Sep 20;14(9):1990-1997. doi: 10.1021/acschembio.9b00463. Epub 2019 Aug 21. ACS Chem Biol. 2019. PMID: 31407891
Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase.
Hayes AJ, Satiaputra J, Sternicki LM, Paparella AS, Feng Z, Lee KJ, Rodriguez BB, Tieu W, Eijkelkamp BA, Shearwin KE, Pukala TL, Abell AD, Booker GW, Polyak SW. Hayes AJ, et al. Among authors: abell ad. Antibiotics (Basel). 2020 Apr 6;9(4):165. doi: 10.3390/antibiotics9040165. Antibiotics (Basel). 2020. PMID: 32268615 Free PMC article.
177 results