Naik HM - Search Results

1

Chemical inhibitors of hexokinase-2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures.

Naik HM, Kumar S, Reddy JV, Gonzalez JE, McConnell BO, Dhara VG, Wang T, Yu M, Antoniewicz MR, Betenbaugh MJ. Naik HM, et al. Biotechnol Bioeng. 2023 Sep;120(9):2559-2577. doi: 10.1002/bit.28417. Epub 2023 May 6. Biotechnol Bioeng. 2023. PMID: 37148536

2

Recombinant Antibody Production in CHO and NS0 Cells: Differences and Similarities.

Dhara VG, Naik HM, Majewska NI, Betenbaugh MJ. Dhara VG, et al. Among authors: naik hm. BioDrugs. 2018 Dec;32(6):571-584. doi: 10.1007/s40259-018-0319-9. BioDrugs. 2018. PMID: 30499081 Review.

3

Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.

Klein SL, Pekosz A, Park HS, Ursin RL, Shapiro JR, Benner SE, Littlefield K, Kumar S, Naik HM, Betenbaugh MJ, Shrestha R, Wu AA, Hughes RM, Burgess I, Caturegli P, Laeyendecker O, Quinn TC, Sullivan D, Shoham S, Redd AD, Bloch EM, Casadevall A, Tobian AA. Klein SL, et al. Among authors: naik hm. J Clin Invest. 2020 Nov 2;130(11):6141-6150. doi: 10.1172/JCI142004. J Clin Invest. 2020. PMID: 32764200 Free PMC article.

4

Chemical speciation of trace metals in mammalian cell culture media: looking under the hood to boost cellular performance and product quality.

Stone AT, Dhara VG, Naik HM, Aliyu L, Lai J, Jenkins J, Betenbaugh MJ. Stone AT, et al. Among authors: naik hm. Curr Opin Biotechnol. 2021 Oct;71:216-224. doi: 10.1016/j.copbio.2021.08.004. Epub 2021 Aug 31. Curr Opin Biotechnol. 2021. PMID: 34478939 Review.

5

A genome-scale nutrient minimization forecast algorithm for controlling essential amino acid levels in CHO cell cultures.

Chen Y, Liu X, Anderson JYL, Naik HM, Dhara VG, Chen X, Harris GA, Betenbaugh MJ. Chen Y, et al. Among authors: naik hm. Biotechnol Bioeng. 2022 Feb;119(2):435-451. doi: 10.1002/bit.27994. Epub 2021 Dec 2. Biotechnol Bioeng. 2022. PMID: 34811743

6

Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing.

Cordova LT, Dahodwala H, Elliott KS, Baik J, Odenewelder DC, Nmagu D, Skelton BA, Uy L, Klaubert SR, Synoground BF, Chitwood DG, Dhara VG, Naik HM, Morris CS, Yoon S, Betenbaugh M, Coffman J, Swartzwelder F, Gillmeister MP, Harcum SW, Lee KH. Cordova LT, et al. Among authors: naik hm. Biotechnol Bioeng. 2023 Mar;120(3):715-725. doi: 10.1002/bit.28290. Epub 2022 Dec 1. Biotechnol Bioeng. 2023. PMID: 36411514

7

Cottonseed hydrolysate supplementation alters metabolic and proteomics responses in Chinese hamster ovary cell cultures.

Dhara VG, Kumar S, DeVine L, Naik HM, Cole RN, More AJ, Lau EC, Betenbaugh MJ. Dhara VG, et al. Among authors: naik hm. Biotechnol J. 2023 Jun;18(6):e2200243. doi: 10.1002/biot.202200243. Epub 2023 Apr 11. Biotechnol J. 2023. PMID: 36892270

8

Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using ¹³C labeling experiments and kinetic modeling.

Naik HM, Cai X, Ladiwala P, Reddy JV, Betenbaugh MJ, Antoniewicz MR. Naik HM, et al. Metab Eng. 2024 May;83:12-23. doi: 10.1016/j.ymben.2024.03.002. Epub 2024 Mar 7. Metab Eng. 2024. PMID: 38460784 Free article.

9

Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism.

Ladiwala P, Cai X, Naik HM, Aliyu L, Schilling M, Antoniewicz MR, Betenbaugh MJ. Ladiwala P, et al. Among authors: naik hm. Metab Eng. 2024 Sep;85:105-115. doi: 10.1016/j.ymben.2024.07.008. Epub 2024 Jul 22. Metab Eng. 2024. PMID: 39047893 Free article.

10

Comprehensive stable-isotope tracing of glucose and amino acids identifies metabolic by-products and their sources in CHO cell culture.

Gonzalez JE, Naik HM, Oates EH, Dhara VG, McConnell BO, Kumar S, Betenbaugh MJ, Antoniewicz MR. Gonzalez JE, et al. Among authors: naik hm. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2403033121. doi: 10.1073/pnas.2403033121. Epub 2024 Oct 4. Proc Natl Acad Sci U S A. 2024. PMID: 39365816

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