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Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation.
Chernyaeva L, Ratti G, Teirilä L, Fudo S, Rankka U, Pelkonen A, Korhonen P, Leskinen K, Keskitalo S, Salokas K, Gkolfinopoulou C, Crompton KE, Javanainen M, Happonen L, Varjosalo M, Malm T, Leinonen V, Chroni A, Saavalainen P, Meri S, Kajander T, Wollman AJ, Nissilä E, Haapasalo K. Chernyaeva L, et al. Among authors: korhonen p. EMBO Rep. 2023 Jul 5;24(7):e56467. doi: 10.15252/embr.202256467. Epub 2023 May 8. EMBO Rep. 2023. PMID: 37155564 Free PMC article.
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo.
Keuters MH, Keksa-Goldsteine V, Dhungana H, Huuskonen MT, Pomeshchik Y, Savchenko E, Korhonen PK, Singh Y, Wojciechowski S, Lehtonen Š, Kanninen KM, Malm T, Sirviö J, Muona A, Koistinaho M, Goldsteins G, Koistinaho J. Keuters MH, et al. Sci Rep. 2021 Feb 10;11(1):3518. doi: 10.1038/s41598-021-81741-3. Sci Rep. 2021. PMID: 33568697 Free PMC article.
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids.
Fagerlund I, Dougalis A, Shakirzyanova A, Gómez-Budia M, Pelkonen A, Konttinen H, Ohtonen S, Fazaludeen MF, Koskuvi M, Kuusisto J, Hernández D, Pebay A, Koistinaho J, Rauramaa T, Lehtonen Š, Korhonen P, Malm T. Fagerlund I, et al. Among authors: korhonen p. Cells. 2021 Dec 30;11(1):124. doi: 10.3390/cells11010124. Cells. 2021. PMID: 35011686 Free PMC article.
Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation.
Byts N, Sharma S, Malm T, Kaakinen M, Korhonen P, Jaakkonen L, Keuters M, Huuskonen M, Pietilä I, Koistinaho J, Koivunen P, Myllyharju J. Byts N, et al. Among authors: korhonen p. J Biol Chem. 2022 Mar;298(3):101721. doi: 10.1016/j.jbc.2022.101721. Epub 2022 Feb 11. J Biol Chem. 2022. PMID: 35151685 Free PMC article.
447 results