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Page 1
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Ko Y, Hong M, Lee S, Kumar M, Ibrahim L, Nutsch K, Stanton C, Sondermann P, Sandoval B, Bulos ML, Iaconelli J, Chatterjee AK, Wiseman RL, Schultz PG, Bollong MJ. Ko Y, et al. Among authors: nutsch k. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2300763120. doi: 10.1073/pnas.2300763120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155889 Free PMC article.
YAP-dependent proliferation by a small molecule targeting annexin A2.
Shalhout SZ, Yang PY, Grzelak EM, Nutsch K, Shao S, Zambaldo C, Iaconelli J, Ibrahim L, Stanton C, Chadwick SR, Chen E, DeRan M, Li S, Hull M, Wu X, Chatterjee AK, Shen W, Camargo FD, Schultz PG, Bollong MJ. Shalhout SZ, et al. Among authors: nutsch k. Nat Chem Biol. 2021 Jul;17(7):767-775. doi: 10.1038/s41589-021-00755-0. Epub 2021 Mar 15. Nat Chem Biol. 2021. PMID: 33723431
Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.
Stanton C, Sun J, Nutsch K, Rosarda JD, Nguyen T, Li-Ma C, Kutseikin S, Saez E, Teijaro JR, Wiseman RL, Bollong MJ. Stanton C, et al. Among authors: nutsch k. bioRxiv [Preprint]. 2023 Jun 1:2023.06.01.543248. doi: 10.1101/2023.06.01.543248. bioRxiv. 2023. Update in: ACS Chem Biol. 2024 Feb 16;19(2):254-265. doi: 10.1021/acschembio.3c00330 PMID: 37398499 Free PMC article. Updated. Preprint.
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.
Ibrahim L, Stanton C, Nutsch K, Nguyen T, Li-Ma C, Ko Y, Lander GC, Wiseman RL, Bollong MJ. Ibrahim L, et al. Among authors: nutsch k. Cell Chem Biol. 2023 Oct 19;30(10):1295-1302.e4. doi: 10.1016/j.chembiol.2023.07.014. Epub 2023 Aug 23. Cell Chem Biol. 2023. PMID: 37619563 Free PMC article.
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly.
Stanton C, Sun J, Nutsch K, Rosarda JD, Nguyen T, Li-Ma C, Njomen E, Melillo B, Kutseikin S, Saez E, Cravatt BF, Teijaro JR, Wiseman RL, Bollong MJ. Stanton C, et al. Among authors: nutsch k. ACS Chem Biol. 2024 Feb 16;19(2):254-265. doi: 10.1021/acschembio.3c00330. Epub 2024 Jan 10. ACS Chem Biol. 2024. PMID: 38198472 Free PMC article.
TERT activation targets DNA methylation and multiple aging hallmarks.
Shim HS, Iaconelli J, Shang X, Li J, Lan ZD, Jiang S, Nutsch K, Beyer BA, Lairson LL, Boutin AT, Bollong MJ, Schultz PG, DePinho RA. Shim HS, et al. Among authors: nutsch k. Cell. 2024 Jul 25;187(15):4030-4042.e13. doi: 10.1016/j.cell.2024.05.048. Epub 2024 Jun 21. Cell. 2024. PMID: 38908367
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