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Page 1
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. Minhas PS, et al. Among authors: ullian em. Science. 2024 Aug 23;385(6711):eabm6131. doi: 10.1126/science.abm6131. Epub 2024 Aug 23. Science. 2024. PMID: 39172838
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Uenaka T, Wang Q, Mhatre SD, Liu L, Conley T, Ennerfelt H, Jung YJ, Prasad P, Jenkins BC, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Ullian EM, Serrano GE, Beach TG, Rabinowitz JD, Wernig M, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. Minhas PS, et al. Among authors: ullian em. bioRxiv [Preprint]. 2024 Jun 28:2024.06.23.598940. doi: 10.1101/2024.06.23.598940. bioRxiv. 2024. Update in: Science. 2024 Aug 23;385(6711):eabm6131. doi: 10.1126/science.abm6131 PMID: 38979192 Free PMC article. Updated. Preprint.
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.
Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Martinez D, Draeger N, Teter OM, Samelson AJ, Pierce N, Ullian EM, Kampmann M. Li E, et al. Among authors: ullian em. bioRxiv [Preprint]. 2024 Nov 24:2023.04.26.538498. doi: 10.1101/2023.04.26.538498. bioRxiv. 2024. PMID: 37163077 Free PMC article. Preprint.
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.
de Majo M, Koontz M, Marsan E, Salinas N, Ramsey A, Kuo YM, Seo K, Li H, Dräger N, Leng K, Gonzales SL, Kurnellas M, Miyaoka Y, Klim JR, Kampmann M, Ward ME, Huang EJ, Ullian EM. de Majo M, et al. Among authors: ullian em. Stem Cell Reports. 2023 Mar 14;18(3):706-719. doi: 10.1016/j.stemcr.2023.01.012. Epub 2023 Feb 23. Stem Cell Reports. 2023. PMID: 36827976 Free PMC article.
Machine learning dissection of human accelerated regions in primate neurodevelopment.
Whalen S, Inoue F, Ryu H, Fair T, Markenscoff-Papadimitriou E, Keough K, Kircher M, Martin B, Alvarado B, Elor O, Laboy Cintron D, Williams A, Hassan Samee MA, Thomas S, Krencik R, Ullian EM, Kriegstein A, Rubenstein JL, Shendure J, Pollen AA, Ahituv N, Pollard KS. Whalen S, et al. Among authors: ullian em. Neuron. 2023 Mar 15;111(6):857-873.e8. doi: 10.1016/j.neuron.2022.12.026. Epub 2023 Jan 13. Neuron. 2023. PMID: 36640767 Free PMC article.
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley WW, Miller BL, Ullian EM, Krummel MF, Kriegstein AR, Huang EJ. Marsan E, et al. Among authors: ullian em. J Clin Invest. 2023 Mar 15;133(6):e164919. doi: 10.1172/JCI164919. J Clin Invest. 2023. PMID: 36602862 Free PMC article.
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. Leng K, et al. Among authors: ullian em. Nat Neurosci. 2022 Nov;25(11):1528-1542. doi: 10.1038/s41593-022-01180-9. Epub 2022 Oct 27. Nat Neurosci. 2022. PMID: 36303069 Free PMC article.
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.
Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X. Tsai NY, et al. Among authors: ullian em. Nat Neurosci. 2022 May;25(5):659-674. doi: 10.1038/s41593-022-01068-8. Epub 2022 May 6. Nat Neurosci. 2022. PMID: 35524141 Free PMC article.
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR. Magill ST, et al. Among authors: ullian em. Nat Commun. 2020 Sep 23;11(1):4803. doi: 10.1038/s41467-020-18582-7. Nat Commun. 2020. PMID: 32968068 Free PMC article.
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV Jr, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. Zhang J, et al. Among authors: ullian em. Nature. 2020 Dec;588(7838):459-465. doi: 10.1038/s41586-020-2709-7. Epub 2020 Aug 31. Nature. 2020. PMID: 32866962 Free PMC article.
56 results