Shi H - Search Results

1

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state.

Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT. Weichert-Leahey N, et al. Among authors: shi h. J Clin Invest. 2023 May 15;133(10):e166919. doi: 10.1172/JCI166919. J Clin Invest. 2023. PMID: 37183825 Free PMC article.

2

Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.

Tao T, Shi H, Guan Y, Huang D, Chen Y, Lane DP, Chen J, Peng J. Tao T, et al. Among authors: shi h. Cell Res. 2013 May;23(5):620-34. doi: 10.1038/cr.2013.16. Epub 2013 Jan 29. Cell Res. 2013. PMID: 23357851 Free PMC article.

3

Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish.

Tao T, Shi H, Huang D, Peng J. Tao T, et al. Among authors: shi h. PLoS One. 2013 Apr 12;8(4):e58858. doi: 10.1371/journal.pone.0058858. Print 2013. PLoS One. 2013. PMID: 23593122 Free PMC article.

4

A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function.

Shi H, Tao T, Huang D, Ou Z, Chen J, Peng J. Shi H, et al. Nucleic Acids Res. 2015 Jan;43(2):1035-43. doi: 10.1093/nar/gku1359. Epub 2014 Dec 29. Nucleic Acids Res. 2015. PMID: 25550427 Free PMC article.

5

Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.

Guan Y, Huang D, Chen F, Gao C, Tao T, Shi H, Zhao S, Liao Z, Lo LJ, Wang Y, Chen J, Peng J. Guan Y, et al. Among authors: shi h. PLoS Biol. 2016 Sep 22;14(9):e1002555. doi: 10.1371/journal.pbio.1002555. eCollection 2016 Sep. PLoS Biol. 2016. PMID: 27657329 Free PMC article.

6

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

Oppel F, Tao T, Shi H, Ross KN, Zimmerman MW, He S, Tong G, Aster JC, Look AT. Oppel F, et al. Among authors: shi h. PLoS Genet. 2019 Apr 10;15(4):e1008039. doi: 10.1371/journal.pgen.1008039. eCollection 2019 Apr. PLoS Genet. 2019. PMID: 30970016 Free PMC article.

7

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.

Tao T, Shi H, Mariani L, Abraham BJ, Durbin AD, Zimmerman MW, Powers JT, Missios P, Ross KN, Perez-Atayde AR, Bulyk ML, Young RA, Daley GQ, Look AT. Tao T, et al. Among authors: shi h. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16516-16526. doi: 10.1073/pnas.1922692117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601179 Free PMC article.

8

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.

Oppel F, Ki DH, Zimmerman MW, Ross KN, Tao T, Shi H, He S, Aster JC, Look AT. Oppel F, et al. Among authors: shi h. Dis Model Mech. 2020 Aug 27;13(8):dmm042341. doi: 10.1242/dmm.042341. Dis Model Mech. 2020. PMID: 32651197 Free PMC article.

9

Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors.

Tao T, Shi H, Wang M, Perez-Atayde AR, London WB, Gutierrez A, Lemos B, Durbin AD, Look AT. Tao T, et al. Among authors: shi h. J Exp Med. 2020 Oct 5;217(10):e20191871. doi: 10.1084/jem.20191871. J Exp Med. 2020. PMID: 32728700 Free PMC article.

10

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression.

Shi H, Tao T, Abraham BJ, Durbin AD, Zimmerman MW, Kadoch C, Look AT. Shi H, et al. Sci Adv. 2020 Jul 15;6(29):eaaz3440. doi: 10.1126/sciadv.aaz3440. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832616 Free PMC article.

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