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Page 1
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
Otake K, Ubukata M, Nagahashi N, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: ubukata m. ACS Med Chem Lett. 2023 Apr 7;14(5):658-665. doi: 10.1021/acsmedchemlett.3c00067. eCollection 2023 May 11. ACS Med Chem Lett. 2023. PMID: 37197451 Free PMC article.
Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors.
Shiozaki M, Maeda K, Miura T, Kotoku M, Yamasaki T, Matsuda I, Aoki K, Yasue K, Imai H, Ubukata M, Suma A, Yokota M, Hotta T, Tanaka M, Hase Y, Haas J, Fryer AM, Laird ER, Littmann NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y, Yoshiuchi H, Inaba T. Shiozaki M, et al. Among authors: ubukata m. J Med Chem. 2011 Apr 28;54(8):2839-63. doi: 10.1021/jm101609j. Epub 2011 Mar 21. J Med Chem. 2011. PMID: 21417219
Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
Otake K, Hara Y, Ubukata M, Inoue M, Nagahashi N, Motoda D, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: ubukata m. J Med Chem. 2024 Mar 14;67(5):3741-3763. doi: 10.1021/acs.jmedchem.3c02171. Epub 2024 Feb 26. J Med Chem. 2024. PMID: 38408347
Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCbeta-selective inhibitors.
Tanaka M, Sagawa S, Hoshi J, Shimoma F, Yasue K, Ubukata M, Ikemoto T, Hase Y, Takahashi M, Sasase T, Ueda N, Matsushita M, Inaba T. Tanaka M, et al. Among authors: ubukata m. Bioorg Med Chem. 2006 Sep 1;14(17):5781-94. doi: 10.1016/j.bmc.2006.05.033. Epub 2006 Jun 9. Bioorg Med Chem. 2006. PMID: 16762554
Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity.
Iida T, Ubukata M, Mitani I, Nakagawa Y, Maeda K, Imai H, Ogoshi Y, Hotta T, Sakata S, Sano R, Morinaga H, Negoro T, Oshida S, Tanaka M, Inaba T. Iida T, et al. Among authors: ubukata m. Eur J Med Chem. 2018 Oct 5;158:832-852. doi: 10.1016/j.ejmech.2018.09.003. Eur J Med Chem. 2018. PMID: 30248655
192 results