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Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness.
Rosen BP, Li QV, Cho HS, Liu D, Yang D, Graff S, Yan J, Luo R, Verma N, Damodaran JR, Kale HT, Kaplan SJ, Beer MA, Sidoli S, Huangfu D. Rosen BP, et al. Among authors: yan j. bioRxiv [Preprint]. 2024 Sep 1:2023.05.03.539283. doi: 10.1101/2023.05.03.539283. bioRxiv. 2024. Update in: Nat Commun. 2024 Oct 17;15(1):8966. doi: 10.1038/s41467-024-53284-4 PMID: 37205540 Free PMC article. Updated. Preprint.
Epigenome rewiring in human pluripotent stem cells.
Yan J, Huangfu D. Yan J, et al. Trends Cell Biol. 2022 Mar;32(3):259-271. doi: 10.1016/j.tcb.2021.12.001. Epub 2021 Dec 23. Trends Cell Biol. 2022. PMID: 34955367 Free PMC article. Review.
Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions.
Luo R, Yan J, Oh JW, Xi W, Shigaki D, Wong W, Cho H, Murphy D, Cutler R, Rosen BP, Pulecio J, Yang D, Glenn R, Chen T, Li QV, Vierbuchen T, Sidoli S, Apostolou E, Huangfu D, Beer MA. Luo R, et al. Among authors: yan j. bioRxiv [Preprint]. 2023 Mar 9:2023.03.07.531569. doi: 10.1101/2023.03.07.531569. bioRxiv. 2023. Update in: Nat Genet. 2023 Aug;55(8):1336-1346. doi: 10.1038/s41588-023-01450-7 PMID: 36945628 Free PMC article. Updated. Preprint.
Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells.
Pulecio J, Tayyebi Z, Liu D, Wong W, Luo R, Damodaran JR, Kaplan S, Cho H, Yan J, Murphy D, Rickert RW, Shukla A, Zhong A, González F, Yang D, Li W, Zhou T, Apostolou E, Leslie CS, Huangfu D. Pulecio J, et al. Among authors: yan j. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544990. doi: 10.1101/2023.06.14.544990. bioRxiv. 2023. PMID: 37398096 Free PMC article. Preprint.
CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant.
Kaplan SJ, Wong W, Yan J, Pulecio J, Cho HS, Li Q, Zhao J, Leslie-Iyer J, Kazakov J, Murphy D, Luo R, Dey KK, Apostolou E, Leslie CS, Huangfu D. Kaplan SJ, et al. Among authors: yan j. bioRxiv [Preprint]. 2024 Jun 28:2024.04.26.591412. doi: 10.1101/2024.04.26.591412. bioRxiv. 2024. Update in: Cell Rep. 2024 Aug 27;43(8):114640. doi: 10.1016/j.celrep.2024.114640 PMID: 38746154 Free PMC article. Updated. Preprint.
Revisiting the role of light signaling in plant responses to salt stress.
Peng Y, Zhu H, Wang Y, Kang J, Hu L, Li L, Zhu K, Yan J, Bu X, Wang X, Zhang Y, Sun X, Ahammed GJ, Jiang C, Meng S, Liu Y, Sun Z, Qi M, Li T, Wang F. Peng Y, et al. Among authors: yan j. Hortic Res. 2024 Sep 16;12(1):uhae262. doi: 10.1093/hr/uhae262. eCollection 2025 Jan. Hortic Res. 2024. PMID: 39802741 Free PMC article.
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