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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: anderson ke. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.
Signalling via phosphoinositide 3OH kinases.
Hawkins PT, Welch H, McGregor A, Eguinoa A, Gobert S, Krugmann S, Anderson K, Stokoe D, Stephens L. Hawkins PT, et al. Biochem Soc Trans. 1997 Nov;25(4):1147-51. doi: 10.1042/bst0251147. Biochem Soc Trans. 1997. PMID: 9449965 Review. No abstract available.
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.
Ellson CD, Anderson KE, Morgan G, Chilvers ER, Lipp P, Stephens LR, Hawkins PT. Ellson CD, et al. Among authors: anderson ke. Curr Biol. 2001 Oct 16;11(20):1631-5. doi: 10.1016/s0960-9822(01)00447-x. Curr Biol. 2001. PMID: 11676926 Free article.
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT. Condliffe AM, et al. Among authors: anderson ke. Blood. 2005 Aug 15;106(4):1432-40. doi: 10.1182/blood-2005-03-0944. Epub 2005 May 5. Blood. 2005. PMID: 15878979 Free article.
828 results