Vanhaesebroeck B - Search Results

1

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: vanhaesebroeck b. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.

2

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

Ji H, Rintelen F, Waltzinger C, Bertschy Meier D, Bilancio A, Pearce W, Hirsch E, Wymann MP, Rückle T, Camps M, Vanhaesebroeck B, Okkenhaug K, Rommel C. Ji H, et al. Among authors: vanhaesebroeck b. Blood. 2007 Oct 15;110(8):2940-7. doi: 10.1182/blood-2007-04-086751. Epub 2007 Jul 12. Blood. 2007. PMID: 17626838 Free article.

3

Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.

Vanhaesebroeck B, Timmers HT, Pronk GJ, van Roy F, Van der Eb AJ, Fiers W. Vanhaesebroeck B, et al. Virology. 1990 Jun;176(2):362-8. doi: 10.1016/0042-6822(90)90006-d. Virology. 1990. PMID: 2140628

4

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W. Schulze-Osthoff K, et al. Among authors: vanhaesebroeck b. J Biol Chem. 1992 Mar 15;267(8):5317-23. J Biol Chem. 1992. PMID: 1312087 Free article.

5

Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages.

Leverrier Y, Okkenhaug K, Sawyer C, Bilancio A, Vanhaesebroeck B, Ridley AJ. Leverrier Y, et al. Among authors: vanhaesebroeck b. J Biol Chem. 2003 Oct 3;278(40):38437-42. doi: 10.1074/jbc.M306649200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12869549 Free article.

6

Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride.

Beyaert R, De Potter C, Vanhaesebroeck B, Van Roy F, Fiers W. Beyaert R, et al. Among authors: vanhaesebroeck b. Am J Pathol. 1991 Mar;138(3):727-39. Am J Pathol. 1991. PMID: 1848044 Free PMC article.

7

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.

Kang S, Denley A, Vanhaesebroeck B, Vogt PK. Kang S, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1289-94. doi: 10.1073/pnas.0510772103. Epub 2006 Jan 23. Proc Natl Acad Sci U S A. 2006. PMID: 16432180 Free PMC article.

8

Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.

Maxwell MJ, Tsantikos E, Kong AM, Vanhaesebroeck B, Tarlinton DM, Hibbs ML. Maxwell MJ, et al. Among authors: vanhaesebroeck b. J Autoimmun. 2012 Jun;38(4):381-91. doi: 10.1016/j.jaut.2012.04.001. Epub 2012 Apr 25. J Autoimmun. 2012. PMID: 22537464

9

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B. Geering B, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7809-14. doi: 10.1073/pnas.0700373104. Epub 2007 Apr 30. Proc Natl Acad Sci U S A. 2007. PMID: 17470792 Free PMC article.

10

Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.

Spender LC, Lucchesi W, Bodelon G, Bilancio A, Karstegl CE, Asano T, Dittrich-Breiholz O, Kracht M, Vanhaesebroeck B, Farrell PJ. Spender LC, et al. Among authors: vanhaesebroeck b. J Gen Virol. 2006 Oct;87(Pt 10):2859-2867. doi: 10.1099/vir.0.82128-0. J Gen Virol. 2006. PMID: 16963743

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