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Page 1
CRISPR-Cas antimicrobials: Challenges and future prospects.
Pursey E, Sünderhauf D, Gaze WH, Westra ER, van Houte S. Pursey E, et al. PLoS Pathog. 2018 Jun 14;14(6):e1006990. doi: 10.1371/journal.ppat.1006990. eCollection 2018 Jun. PLoS Pathog. 2018. PMID: 29902258 Free PMC article. No abstract available.
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro.
Daruka L, Czikkely MS, Szili P, Farkas Z, Balogh D, Grézal G, Maharramov E, Vu TH, Sipos L, Juhász S, Dunai A, Daraba A, Számel M, Sári T, Stirling T, Vásárhelyi BM, Ari E, Christodoulou C, Manczinger M, Enyedi MZ, Jaksa G, Kovács K, van Houte S, Pursey E, Pintér L, Haracska L, Kintses B, Papp B, Pál C. Daruka L, et al. Among authors: pursey e. Nat Microbiol. 2025 Jan 13. doi: 10.1038/s41564-024-01891-8. Online ahead of print. Nat Microbiol. 2025. PMID: 39805953
The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape.
Maestri A, Pons BJ, Pursey E, Chong CE, Gandon S, Custodio R, Olina A, Agapov A, Chisnall MAW, Grasso A, Paterson S, Szczelkun MD, Baker KS, van Houte S, Chevallereau A, Westra ER. Maestri A, et al. Among authors: pursey e. Cell Host Microbe. 2024 Aug 14;32(8):1412-1426.e11. doi: 10.1016/j.chom.2024.07.005. Epub 2024 Aug 1. Cell Host Microbe. 2024. PMID: 39094583 Free article.